当前位置: X-MOL 学术Inflammation › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Characteristics and Role of Neutrophil Extracellular Traps in Asthma
Inflammation ( IF 5.1 ) Pub Date : 2021-09-04 , DOI: 10.1007/s10753-021-01526-8
Fei Chen 1 , Min Yu 2 , Yonghong Zhong 2 , Lina Wang 1 , Huaqiong Huang 1
Affiliation  

Asthma is a common chronic respiratory disease that affects millions of people worldwide. The incidence of asthma has continued to increase every year. Bronchial asthma involves a variety of cells, including airway inflammatory cells, structural cells, and neutrophils, which have gained more attention because they secrete substances that play an important role in the occurrence and development of asthma. Neutrophil extracellular traps (NETs) are mesh-like structures composed of DNA, histones, and non-histone molecules that can be secreted from neutrophils. NETs can enrich anti-bacterial substances and limit pathogen migration, thus having a protective effect in case of inflammation. However, despite of their anti-inflammatory properties, NETs have been shown to trigger allergic asthma and worsen asthma progression. Here, we provide a systematic review of the roles of NETs in asthma.



中文翻译:

中性粒细胞胞外陷阱在哮喘中的特征及作用

哮喘是一种常见的慢性呼吸道疾病,影响着全世界数百万人。哮喘的发病率逐年增加。支气管哮喘涉及多种细胞,包括气道炎症细胞、结构细胞、中性粒细胞等,由于它们分泌的物质对哮喘的发生和发展起重要作用,因此受到了越来越多的关注。中性粒细胞胞外陷阱 (NET) 是由 DNA、组蛋白和可从中性粒细胞分泌的非组蛋白分子组成的网状结构。NETs 可以富集抗菌物质并限制病原体迁移,从而在发生炎症时具有保护作用。然而,尽管具有抗炎特性,NETs 已被证明会引发过敏性哮喘并恶化哮喘进展。这里,

更新日期:2021-09-04
down
wechat
bug