This highlight presents a recent technique of “Light Vaccine” for COVID-19 pandemic control. Though this technique has the germicidal advantage to SARS-CoV-2, its shortcomings will limit the wide and in-depth application. We make a perspective of real nano light vaccine, which will play an important role in the prevention and control of COVID-19. Briefly, This flow chart described the MWCNT was fabricated with strong acid and base conditional mixture in order to achieve the p-WCNT (chemical process); then modified with RNA layse and receptor binding domain (RBD) by covalent conjugation and physical absorption to get f-WCNT (functionalization); thereafter, f-WCNT was used in the multi-cell culture system interacting with SARS-CoV-2 to identify the special affinity of f-WCNT to ACE2 labeled alveolar type II cells and the inhibition capacity to SARS-CoV-2. This design, is different from the so called “light vaccine”, has the real function to against SARS-CoV-2 by local cellular temperature-rising through photothermal conversion under the near infrared (NIR) light irradiation, according to the physical and chemical nature of carbon nanotubes, and initiates the immune response consequently.

本次重点介绍了用于 COVID-19 大流行控制的“轻型疫苗”的最新技术。该技术虽然对SARS-CoV-2具有杀菌优势，但其缺点将限制其广泛深入的应用。我们透视真正的纳米光疫苗，它将在COVID-19的预防和控制中发挥重要作用。简而言之，该流程图描述了 MWCNT 是用强酸和强碱条件混合物制造的，以实现 p-WCNT（化学过程）；然后通过共价结合和物理吸收，用 RNA 酶和受体结合域 (RBD) 进行修饰，得到 f-WCNT（功能化）；此后，f-WCNT 用于与 SARS-CoV-2 相互作用的多细胞培养系统，以鉴定 f-WCNT 对 ACE2 标记的肺泡 II 型细胞的特殊亲和力以及对 SARS-CoV-2 的抑制能力。这种设计不同于所谓的“光疫苗”，根据物理和化学性质，在近红外 (NIR) 光照射下，通过光热转换使局部细胞升温，从而真正具有对抗 SARS-CoV-2 的功能。碳纳米管的性质，并因此启动免疫反应。