Individual tumor genomics plays a key role in determining patient prognosis, response to chemotherapy and in guiding therapy. In prior studies, it was shown that the degree of late enhancement of colorectal liver metastases (CRCLM) target tumor enhancement (TTE) as seen on magnetic resonance imaging (MRI) was associated with overall survival. In order to better understand the relationship between MRI enhancement and survival, the aim of this study was to characterize genomic profiles of tumors clustered by MRI TTE, and investigate the association between TTE and genetic mutations.

中文翻译：

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结直肠癌肝转移的延迟 MRI 增强与转移突变谱相关。

个体肿瘤基因组学在确定患者预后、对化疗的反应和指导治疗方面起着关键作用。在先前的研究中，表明在磁共振成像 (MRI) 上看到的结直肠肝转移 (CRCLM) 靶肿瘤增强 (TTE) 的晚期增强程度与总生存率相关。为了更好地了解 MRI 增强与生存之间的关系，本研究的目的是表征由 MRI TTE 聚集的肿瘤的基因组谱，并研究 TTE 与基因突变之间的关联。