Response to the letter, entitled “Role of hemagglutinin esterase protein in neurological manifestation of COVID-19”,Fluids and Barriers of the CNS

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Response to the letter, entitled “Role of hemagglutinin esterase protein in neurological manifestation of COVID-19”
Fluids and Barriers of the CNS ( IF 7.3 ) Pub Date : 2021-09-03 , DOI: 10.1186/s12987-021-00275-y
Rashid Deane ₁

Affiliation

In the letter to the Editor, entitled “Role of hemagglutinin esterase protein in neurological manifestation of COVID-19”, the authors [1] appear to indicate that a role was attributed to hemagglutinin esterase (HE) in the coronavirus disease 2019 (COVID-19) neurological manifestation in a recent review article [2]. However, in this review HE is mentioned once but there is no discussion on its function. In addition, there is no speculation on HE’s role in COVID-19 and specifically on the neurological manifestations of this infection in the review [2].

At the time the manuscript of the review was prepared, there were articles, which contain diagrammatic figures of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) with HE and/or descriptions of HE as a structural component [3,4,5]. Also, a more recent article described HE as a structural component of SARS-CoV-2, and there is, also, a diagrammatic figure of SARS-CoV-2 with HE [6]. Thus, there is still ongoing confusion on HE’s presence in SARS-CoV-2.

At the time of the COVID-19 outbreak, information on the virus genomic structure, membrane proteins and their functions were rapidly evolving. Indeed, the completion of the genetic sequencing of SARS-CoV-2 led to the production of effective vaccines, and a better understanding of the virus lineage and the origin of its variants. Thus, the information in the literature on whether HE is present in this virus may be due to the evolving knowledge on the virus, including its structure, function of its various membrane proteins and the etiology of COVID-19.

However, the references used to support the statement on the presence of HE in SARS-CoV-2 were inadvertently removed during the editing process of the review [2]. These are now included in this letter [3, 4].

Not applicable.

1.
Zandi M, Karami H, Soltani S. Role of hemagglutinin esterase protein in neurological manifestation of COVID-19. Fluids Barriers CNS. 2021;18:39.
CAS Article Google Scholar
2.
McQuaid C, Brady M, Deane R. SARS-CoV-2: is there neuroinvasion? Fluids Barriers CNS. 2021;18(1):1–21.
Article Google Scholar
3.
Infantino M, Damiani A, Gobbi FL, Grossi V, Lari B, Macchia D, et al. Serological assays for SARS-CoV-2 infectious disease: benefits, limitations and perspectives. Isr Med Assoc J. 2020;22:203–10.
PubMed Google Scholar
4.
Lahlou Y, El AB, Bamhaoud T. Genomic and molecular analysis of SARS-CoV-2 and the possible strategies of Covid-19 treatment—a review. IOSR J Pharm Biol Sci. 2020;13:39–47.
Google Scholar
5.
Kim CH. Sars-cov-2 evolutionary adaptation toward host entry and recognition of receptor o-acetyl sialylation in virus–host interaction. Int J Mol Sci. 2020;21:1–34.
Google Scholar
6.
Bagheri HS, Karimipour M, Heidarzadeh M, Rajabi H, Sokullu E, Rahbarghazi R. Does the global outbreak of COVID-19 or other viral diseases threaten the stem cell reservoir inside the body? Stem Cell Rev Rep. 2021;17:214–30.
CAS Article Google Scholar

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Funding from the NIH (AG057574 and AG050212 to RD).

From the NIH (AG057574 and AG050212 to RD).

Affiliations

Department of Neuroscience, University of Rochester, URMC, 601 Elmwood Avenue, Rochester, NY, 14642, USA
Rashid Deane

Authors

Rashid DeaneView author publications
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Contributions

RD wrote the letter. The author read and approved the final manuscript.

Corresponding author

Correspondence to Rashid Deane.

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The author declares that there are no competing interests.

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Deane, R. Response to the letter, entitled “Role of hemagglutinin esterase protein in neurological manifestation of COVID-19”. Fluids Barriers CNS 18, 41 (2021). https://doi.org/10.1186/s12987-021-00275-y

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Received: 24 August 2021
Accepted: 26 August 2021
Published: 03 September 2021
DOI: https://doi.org/10.1186/s12987-021-00275-y

中文翻译：

对题为“血凝素酯酶蛋白在 COVID-19 神经系统表现中的作用”的信函的回应

在给编辑的一封题为“血凝素酯酶蛋白在 COVID-19 神经系统表现中的作用”的信中，作者 [1] 似乎表明血凝素酯酶（HE）在 2019 年冠状病毒病（COVID- 19) 最近一篇评论文章中的神经学表现 [2]。然而，在这篇评论中，HE 被提及一次，但没有讨论它的功能。此外，在评价中没有推测 HE 在 COVID-19 中的作用，特别是这种感染的神经系统表现 [2]。

在撰写该综述的手稿时，有一些文章包含严重急性呼吸系统综合症冠状病毒-2 (SARS-CoV-2) 的图解图，其中以 HE 和/或 HE 的描述作为结构组成部分 [3,4 ,5]。此外，最近的一篇文章将 HE 描述为 SARS-CoV-2 的结构组成部分，并且还有一张 SARS-CoV-2 与 HE 的示意图 [6]。因此，关于 HE 在 SARS-CoV-2 中的存在仍然存在混淆。

在 COVID-19 爆发时，有关病毒基因组结构、膜蛋白及其功能的信息正在迅速发展。事实上，SARS-CoV-2 基因测序的完成导致了有效疫苗的生产，并更好地了解了病毒谱系及其变体的起源。因此，文献中关于该病毒中是否存在 HE 的信息可能是由于对该病毒的认识不断发展，包括其结构、各种膜蛋白的功能以及 COVID-19 的病因学。

然而，用于支持关于 SARS-CoV-2 中存在 HE 声明的参考文献在该综述的编辑过程中被无意中删除 [2]。这些现在都包含在这封信中 [3, 4]。

不适用。

1.
Zandi M、Karami H、Soltani S。血凝素酯酶蛋白在 COVID-19 神经系统表现中的作用。流体屏障 CNS。2021；18:39。
CAS 文章 Google Scholar
2.
McQuaid C、Brady M、Deane R. SARS-CoV-2：是否存在神经侵袭？流体屏障 CNS。2021；18(1):1-21。
文章谷歌学术
3.
Infantino M、Damiani A、Gobbi FL、Grossi V、Lari B、Macchia D 等。SARS-CoV-2 传染病的血清学检测：益处、局限性和前景。Isr Med Assoc J. 2020；22:203-10。
考研谷歌学者
4.
Lahlou Y、El AB、Bamhaoud T. SARS-CoV-2 的基因组和分子分析以及 Covid-19 治疗的可能策略——综述。IOSR J Pharm Biol Sci。2020；13:39-47。
谷歌学术
5.
金CH。Sars-cov-2 对宿主进入的进化适应和病毒-宿主相互作用中受体 o-乙酰唾液酸化的识别。国际 J 分子科学。2020；21:1-34。
谷歌学术
6.
Bagheri HS、Karimipour M、Heidarzadeh M、Rajabi H、Sokullu E、Rahbarghazi R. COVID-19 或其他病毒性疾病的全球爆发是否威胁到体内的干细胞库？干细胞修订版 2021 年；17：214-30。
CAS 文章 Google Scholar

下载参考

来自 NIH 的资助（AG057574 和 AG050212 到 RD）。

来自 NIH（AG057574 和 AG050212 到 RD）。

隶属关系

神经科学系，罗彻斯特大学，URMC，601 Elmwood Avenue, Rochester, NY, 14642, USA
拉希德·迪恩

作者

Rashid Deane查看作者出版物
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贡献

RD 写了这封信。作者阅读并批准了最终手稿。

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与拉希德·迪恩的通信。

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不适用。

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