Cervical cancer is one of the most diagnosed and deadly cancers in women globally. Though vaccination is an effective way to reduce cervical cancer, people’s knowledge and acceptance of the vaccination remains a challenge in low and middle-income countries. Therefore, the aim of this study was to assess the level of knowledge and acceptance of Human Papilloma Virus (HPV) vaccination and its associated factors among parents of daughters in Addis Ababa, Ethiopia. A community-based cross-sectional study was conducted among parents or guardians whose daughters are in the age group of 9–17 years and residing in Akaki-Kalty sub-city in Addis Ababa. A multistage sampling technique was used to select the study participants (n = 430). Face-to-face interview was conducted by using a structured questionnaire. Factors associated with the acceptance of HPV vaccination was identified by multivariable binary logistic regression and expressed by adjusted odds ratio (aOR), and respective 95% confidence interval. Complete response was obtained from 422 (98.1%) of the participants and their mean age was 39.0 years (SD ± 9.9). Out of the study participants, 41.7% and 72.0% had poor knowledge on cervical cancer and HPV, respectively. More than a quarter (27.0%) of the participants has never heard about HPV vaccine. One-third (36.5%) of the participants had negative attitude towards the HPV vaccine. Overall, 94.3% of the study participants were willing to vaccinate their daughters for HPV. Vaccine acceptability was associated with higher monthly income (aOR = 2.48, 95% CI 1.08–6.34), good knowledge on HPV (aOR = 2.32, 95% CI 1.56–4.87) and the vaccine (aOR = 2.24, 95% CI 1.12–8.60), and positive attitude towards the vaccine (aOR = 5.03, 95% CI 1.63—9.56). The overall HPV vaccine acceptance was high. However, two out of five and one-thirds of the parents had poor knowledge on cervical cancer and negative attitude towards the HPV vaccine, respectively. Higher monthly income, good knowledge on HPV and the vaccine, and positive attitude towards the vaccine were associated with acceptance of HPV vaccination. To ensure sustainable acceptance of HPV vaccination, it is crucial to increase the community awareness in a sustainable manner.

中文翻译：

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埃塞俄比亚亚的斯亚贝巴女儿父母对 HPV 疫苗接种及其相关因素的了解和接受：一项基于社区的横断面研究

宫颈癌是全球女性中确诊率最高、死亡率最高的癌症之一。尽管疫苗接种是减少宫颈癌的有效方法，但人们对疫苗接种的了解和接受程度在低收入和中等收入国家仍然是一个挑战。因此，本研究的目的是评估埃塞俄比亚亚的斯亚贝巴女儿父母对人乳头瘤病毒 (HPV) 疫苗接种及其相关因素的了解和接受程度。一项基于社区的横断面研究在其女儿年龄在 9-17 岁之间并居住在亚的斯亚贝巴 Akaki-Kalty 子城市的父母或监护人中进行。使用多阶段抽样技术选择研究参与者（n = 430）。面对面访谈采用结构化问卷进行。与接受 HPV 疫苗接种相关的因素通过多变量二元逻辑回归确定，并用调整后的优势比 (aOR) 和各自的 95% 置信区间表示。从 422 (98.1%) 名参与者中获得了完全响应，他们的平均年龄为 39.0 岁 (SD ± 9.9)。在研究参与者中，分别有 41.7% 和 72.0% 的人对宫颈癌和 HPV 知之甚少。超过四分之一 (27.0%) 的参与者从未听说过 HPV 疫苗。三分之一 (36.5%) 的参与者对 HPV 疫苗持负面态度。总体而言，94.3% 的研究参与者愿意为女儿接种 HPV 疫苗。疫苗可接受性与较高的月收入 (aOR = 2.48, 95% CI 1.08–6.34)、对 HPV 的良好了解 (aOR = 2.32, 95% CI 1.56–4.87) 和疫苗 (aOR = 2. 24, 95% CI 1.12-8.60)，以及对疫苗的积极态度 (aOR = 5.03, 95% CI 1.63-9.56)。HPV 疫苗的整体接受度很高。然而，五分之二的父母和三分之一的父母分别对宫颈癌知识不足和对HPV疫苗持消极态度。较高的月收入、对 HPV 和疫苗的了解以及对疫苗的积极态度与接受 HPV 疫苗接种有关。为确保可持续接受 HPV 疫苗接种，以可持续的方式提高社区意识至关重要。分别。较高的月收入、对 HPV 和疫苗的了解以及对疫苗的积极态度与接受 HPV 疫苗接种有关。为确保可持续接受 HPV 疫苗接种，以可持续的方式提高社区意识至关重要。分别。较高的月收入、对 HPV 和疫苗的了解以及对疫苗的积极态度与接受 HPV 疫苗接种有关。为确保可持续接受 HPV 疫苗接种，以可持续的方式提高社区意识至关重要。