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Functional Nucleic Acids for Pathogenic Bacteria Detection
Accounts of Chemical Research ( IF 18.3 ) Pub Date : 2021-09-03 , DOI: 10.1021/acs.accounts.1c00355
Dingran Chang , Sandy Zakaria , Sahar Esmaeili Samani , Yangyang Chang 1 , Carlos D M Filipe , Leyla Soleymani , John D Brennan , Meng Liu 1 , Yingfu Li
Affiliation  

Pathogens have long presented a significant threat to human lives, and hence the rapid detection of infectious pathogens is vital for improving human health. Current detection methods lack the means to detect infectious pathogens in a simple, rapid, and reliable manner at the time and point of need. Functional nucleic acids (FNAs) have the potential to overcome these limitations by acting as key components for point-of-care (POC) biosensors due to their distinctive advantages that include high binding affinities and specificities, excellent chemical stability, ease of synthesis and modification, and compatibility with a variety of signal-amplification and signal-transduction mechanisms.

中文翻译:

用于病原菌检测的功能性核酸

病原体长期以来对人类生命构成重大威胁,因此快速检测传染性病原体对于改善人类健康至关重要。当前的检测方法缺乏在需要的时间和点以简单、快速和可靠的方式检测传染性病原体的手段。功能性核酸 (FNA) 作为即时 (POC) 生物传感器的关键组件,具有克服这些限制的潜力,因为它们具有独特的优势,包括高结合亲和力和特异性、优异的化学稳定性、易于合成和修饰,以及与各种信号放大和信号转导机制的兼容性。
更新日期:2021-09-21
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