The associations between selenium and liver stiffness and steatosis remain uncertain. This study aimed to explore the clinical relevance of selenium with liver stiffness and steatosis in adults from the 2017-2018 National Health and Nutrition Examination Survey. Subjects with excessive alcohol consumption and hepatitis B or C infection were excluded. Liver stiffness and steatosis were detected by transient elastography. Dietary selenium intakes and blood selenium concentrations were included as exposures. In multivariate analysis without adjustment for obesity, higher dietary selenium intakes (tertile 3 vs. tertile 1) were positively associated with liver stiffness in females (odds ratio (95% confidence interval): 2.64 (1.88-3.70)), and were positively associated with liver steatosis overall (1.54 (1.20-1.97)) and also in males (1.55 (1.06-2.26)). In multivariate analysis without adjustment for obesity, higher blood selenium concentrations (tertile 3 vs. tertile 1) were positively associated with liver steatosis overall (1.33 (1.02-1.76)) and also in males (1.56 (1.13-2.16)). After further adjustment for obesity, the abovementioned associations remain significant between dietary selenium intakes and liver stiffness in females (2.29 (1.69-3.12)) and liver steatosis overall (1.37 (1.01-1.86)), and between blood selenium concentrations and liver steatosis in males (1.67 (1.25-2.21)). Dose-response analysis showed that the abovementioned associations were linear. However, dietary selenium intakes meeting the recommended daily allowance (≥ 55 µg/day) were not associated with liver stiffness (0.99 (0.62-1.55)) and steatosis (1.01 (0.69-1.49)). In conclusion, higher dietary selenium intakes and blood selenium concentrations were positively associated with liver stiffness and steatosis, and obesity may partially account for the observed associations.

中文翻译：

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成人瞬时弹性成像检测硒与肝硬化和脂肪变性的临床相关性。

硒与肝脏僵硬和脂肪变性之间的关联仍不确定。本研究旨在探讨硒与 2017-2018 年全国健康和营养检查调查中成人肝脏僵硬和脂肪变性的临床相关性。过度饮酒和乙型或丙型肝炎感染的受试者被排除在外。通过瞬时弹性成像检测肝脏僵硬和脂肪变性。膳食硒摄入量和血硒浓度被包括为暴露量。在未调整肥胖的多变量分析中，较高的膳食硒摄入量（三分位数 3 与三分位数 1）与女性肝脏硬度呈正相关（优势比（95% 置信区间）：2.64 (1.88-3.70)），并且呈正相关总体肝脂肪变性 (1.54 (1.20-1.97)) 和男性 (1.55 (1.06-2.26))。在未对肥胖进行调整的多变量分析中，较高的血硒浓度（三分位数 3 与三分位数 1）与总体肝脂肪变性（1.33（1.02-1.76））和男性（1.56（1.13-2.16））呈正相关。在对肥胖进行进一步调整后，上述相关性在女性膳食硒摄入量和肝脏硬度 (2.29 (1.69-3.12)) 和总体肝脏脂肪变性 (1.37 (1.01-1.86)) 之间以及血液硒浓度和肝脏脂肪变性之间仍然显着。男性 (1.67 (1.25-2.21))。剂量反应分析表明，上述关联是线性的。然而，达到推荐的每日摄入量（≥ 55 µg/天）的膳食硒摄入量与肝脏硬度（0.99（0.62-1.55））和脂肪变性（1.01（0.69-1.49））无关。综上所述，