The numerous complications of diabetes may be at least in part generated by the oxidative stress associated with the constant state of hyperglycemia. Polyphenols are plant-based secondary metabolites that have high potentials in the prevention and treatment of some diseases, in particular those that involve oxidative stress, such as complications of diabetes. The purpose of this narrative review is to show the main evidence regarding the role of polyphenols in treating and preventing these complications. For the bibliographic research, the papers published up to March 15, 2021, were considered, and the search terms included words relating to polyphenols, their classes and some more known compounds in association with the complications of diabetes. There are numerous studies showing how polyphenols are active against endothelial damage induced by diabetes, oxidative stress and hyperinflammatory states that are at the origin of the complications of diabetes. Compounds such as flavonoids, but also anthocyanins, stilbenes or lignans slow the progression of kidney damage, prevent ischemic events and diabetic nephropathy. Many of these studies are preclinical, in cellular or animal models. The role of polyphenols in the prevention and treatment of diabetes complications is undoubtedly promising. However, more clinical trials need to be implemented to understand the real effectiveness of these compounds.

中文翻译：

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II 型糖尿病慢性并发症的预防和管理：多酚的作用（小型评论）。

糖尿病的众多并发症可能至少部分是由与持续的高血糖状态相关的氧化应激产生的。多酚是基于植物的次级代谢产物，在预防和治疗某些疾病方面具有很高的潜力，特别是那些涉及氧化应激的疾病，例如糖尿病并发症。这篇叙述性综述的目的是展示多酚在治疗和预防这些并发症中的作用的主要证据。对于书目研究，考虑了截至 2021 年 3 月 15 日发表的论文，搜索词包括与多酚、它们的类别和一些与糖尿病并发症相关的更已知化合物相关的词。有许多研究表明多酚如何有效对抗糖尿病引起的内皮损伤、氧化应激和高炎症状态，这些是糖尿病并发症的起源。黄酮类化合物以及花青素、芪或木脂素等化合物可减缓肾损伤的进展，预防缺血性事件和糖尿病肾病。许多这些研究是临床前的，在细胞或动物模型中。多酚在防治糖尿病并发症中的作用无疑是大有可为的。然而，需要进行更多的临床试验来了解这些化合物的真正有效性。芪或木脂素可减缓肾损伤的进展，预防缺血事件和糖尿病肾病。许多这些研究是临床前的，在细胞或动物模型中。多酚在防治糖尿病并发症中的作用无疑是大有可为的。然而，需要进行更多的临床试验来了解这些化合物的真正有效性。芪或木脂素可减缓肾损伤的进展，预防缺血事件和糖尿病肾病。许多这些研究是临床前的，在细胞或动物模型中。多酚在防治糖尿病并发症中的作用无疑是大有可为的。然而，需要进行更多的临床试验来了解这些化合物的真正有效性。