BACKGROUND Allergic rhinitis (AR) is characterized by chronic inflammation of the nasal mucosa. T-helper 2 lymphocytes, neutrophils, and eosinophils play an active role during the late-phase immune response after exposure to allergen. OBJECTIVE We aimed to investigate the usefulness of inflammatory parameters of neutro-phil-to-lymphocyte ratio (NLR), eosinophil-to-neutrophil ratio (ENR), and eosinophil-to- lymphocyte ratio (ELR) as markers for distinction between intermittent and persistent allergic rhinitis. MATERIAL AND METHODS This was a double-center, retrospective study. Patients were enrolled after diagnosed with AR according to the Allergic Rhinitis and Its Impact on Asthma guidelines. Individuals with an active infection were excluded. A cohort of healthy subjects acted as a control group. NLR, ENR, and ELR were calculated using the results obtained from the patients' complete blood count. Descriptive statistical analysis was performed for all studied variables. RESULTS In all, 205 AR patients and 49 healthy individuals were included. AR patients had significantly higher levels of absolute eosinophils, ENR, and ELR, and significantly lower levels of NLR than the healthy controls (P < 0.05). A total of 160 (78%) patients with persistent AR had significantly higher levels of absolute eosinophils, ENR, and ELR, and significantly lower levels of NLR than patients with intermittent AR (P < 0.05). CONCLUSION Currently, classification of severity of AR is based on the patient's anamnesis. It has been shown in this study that serum eosinophil levels in persistent AR patients could be used as traceable parameters in evaluating severity of the disease by looking at the proportions of ENR and ELR. We anticipate that in the future this issue would be supported by a larger number of studies.

中文翻译：

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过敏性鼻炎严重程度与成人中性粒细胞与淋巴细胞、嗜酸性粒细胞与中性粒细胞和嗜酸性粒细胞与淋巴细胞比率的关系。

背景技术过敏性鼻炎(AR)的特征在于鼻粘膜的慢性炎症。T 辅助 2 淋巴细胞、中性粒细胞和嗜酸性粒细胞在接触过敏原后的晚期免疫反应中发挥积极作用。目的 我们旨在研究中性粒细胞与淋巴细胞比率 (NLR)、嗜酸性粒细胞与中性粒细胞比率 (ENR) 和嗜酸性粒细胞与淋巴细胞比率 (ELR) 等炎症参数作为区分间歇性和持续性过敏性鼻炎。材料与方法 这是一项双中心、回顾性研究。根据过敏性鼻炎及其对哮喘的影响指南，患者在诊断为 AR 后入组。有活动性感染的个体被排除在外。一组健康受试者作为对照组。NLR, ENR, 使用从患者的全血细胞计数获得的结果计算 ELR 和 ELR。对所有研究变量进行描述性统计分析。结果 共纳入 205 名 AR 患者和 49 名健康个体。AR患者的嗜酸性粒细胞绝对值、ENR和ELR水平显着高于健康对照组，NLR水平显着低于健康对照组（P < 0.05）。共有 160 名（78%）持续性 AR 患者的绝对嗜酸性粒细胞、ENR 和 ELR 水平显着高于间歇性 AR 患者，而 NLR 水平显着低于间歇性 AR 患者（P < 0.05）。结论 目前，AR 的严​​重程度分类基于患者的病史。本研究表明，通过观察 ENR 和 ELR 的比例，持续性 AR 患者的血清嗜酸性粒细胞水平可用作评估疾病严重程度的可追溯参数。我们预计，将来这个问题将得到更多研究的支持。