OBJECTIVES This study aimed to evaluate the efficacy of air purifier therapy for patients with allergic asthma. METHODS Thirty-eight subjects were categorized under two groups namely treatment group and control group. All subjects were under 18 years of age and they had been clinically diagnosed with allergic asthma. The treatment group used high efficiency particulate air (HEPA) purifiers for six consecutive months, and the control group did not use the air filters. Particulate matter (PM) data and dust samples (from bedding and a static point) were collected from the subjects' bedrooms before they started using the air purifiers and each month thereafter. Simultaneously, the subjects were asked to complete a questionnaire for the Asthma Control Test (ACT) or Childhood Asthma Control Test (C-ACT). Fractional exhaled nitric oxide (FENO) tests were performed at the start and end of the study. The concentrations of Der p1 and Der f1 were measured in the dust samples. RESULTS (1) After utilizing the air purifier, the concentrations of house dust mite (HDM) allergens (Der p1+ Der f1) in the dust samples decreased. In addition, the PMindoor/outdoor values significantly decreased. (2) The ACT and C-ACT scores in the treatment group maintained a steady significant upward trend. (3) At the end of the study, the FENO levels in both groups were lower, although the differences were not significant. CONCLUSIONS It is witnessed that HEPA air purifiers can decrease indoor HDM allergen and PM levels and improve the quality of life for allergic asthma patients.

中文翻译：

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空气净化器治疗过敏性哮喘患者的疗效。

目的 本研究旨在评估空气净化器治疗过敏性哮喘患者的疗效。方法将38名受试者分为两组，即治疗组和对照组。所有受试者均未满 18 岁，临床诊断为过敏性哮喘。治疗组连续六个月使用高效微粒空气（HEPA）净化器，对照组不使用空气过滤器。在受试者开始使用空气净化器之前和之后的每个月，从他们的卧室收集颗粒物 (PM) 数据和灰尘样本（来自床上用品和一个静态点）。同时，要求受试者完成哮喘控制测试（ACT）或儿童哮喘控制测试（C-ACT）的问卷。在研究开始和结束时进行了部分呼出气一氧化氮 (FENO) 测试。在粉尘样品中测量了 Der p1 和 Der f1 的浓度。结果（1）使用空气净化器后，粉尘样品中屋尘螨（HDM）过敏原（Der p1+ Der f1）的浓度降低。此外，PMindoor/outdoor 值显着下降。(2)治疗组ACT和C-ACT评分均保持稳定显着上升趋势。(3)研究结束时，两组的FENO水平均较低，但差异不显着。结论 HEPA 空气净化器可以降低室内 HDM 过敏原和 PM 水平，提高过敏性哮喘患者的生活质量。在粉尘样品中测量了 Der p1 和 Der f1 的浓度。结果（1）使用空气净化器后，粉尘样品中屋尘螨（HDM）过敏原（Der p1+ Der f1）的浓度降低。此外，PMindoor/outdoor 值显着下降。(2)治疗组ACT和C-ACT评分均保持稳定显着上升趋势。(3)研究结束时，两组的FENO水平均较低，但差异不显着。结论 HEPA 空气净化器可以降低室内 HDM 过敏原和 PM 水平，提高过敏性哮喘患者的生活质量。在粉尘样品中测量了 Der p1 和 Der f1 的浓度。结果（1）使用空气净化器后，粉尘样品中屋尘螨（HDM）过敏原（Der p1+ Der f1）的浓度降低。此外，PMindoor/outdoor 值显着下降。(2)治疗组ACT和C-ACT评分均保持稳定显着上升趋势。(3)研究结束时，两组的FENO水平均较低，但差异不显着。结论 HEPA 空气净化器可以降低室内 HDM 过敏原和 PM 水平，提高过敏性哮喘患者的生活质量。PMindoor/outdoor 值显着下降。(2)治疗组ACT和C-ACT评分均保持稳定显着上升趋势。(3)研究结束时，两组的FENO水平均较低，但差异不显着。结论 HEPA 空气净化器可以降低室内 HDM 过敏原和 PM 水平，提高过敏性哮喘患者的生活质量。PMindoor/outdoor 值显着下降。(2)治疗组ACT和C-ACT评分均保持稳定显着上升趋势。(3)研究结束时，两组的FENO水平均较低，但差异不显着。结论 HEPA 空气净化器可以降低室内 HDM 过敏原和 PM 水平，提高过敏性哮喘患者的生活质量。