Hypothermic oxygenated machine perfusion (HOPE) reduces ischaemia–reperfusion injury of donor livers and thereby improves outcomes after transplantation. End-ischaemic normothermic machine perfusion (NMP) enables assessment of hepatobiliary viability and selection of livers that would otherwise have been declined for transplantation. We advocate the combined use of (dual) HOPE and NMP for livers that are considered high risk, but may still be transplanted safely after ex situ resuscitation and assessment of hepatobiliary viability. Combined dual HOPE–NMP has the potential to substantially decrease the high rates of deceased donor liver discard.

中文翻译：

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移植供体肝脏的异位机器保存：所有人的希望？

低温氧合机灌注（HOPE）可减少供体肝脏的缺血再灌注损伤，从而改善移植后的结果。缺血终末常温机器灌注 (NMP) 能够评估肝胆活力并选择否则会拒绝移植的肝脏。我们主张对被认为高风险但在异位复苏和肝胆活力评估后仍可安全移植的肝脏联合使用（双重）HOPE 和 NMP。双 HOPE-NMP 组合有可能大幅降低死亡供体肝脏的高丢弃率。