Background. Primary polydipsia, characterized by excessive fluid intake, carries the risk of water intoxication and hyponatremia, but treatment options are scarce. Glucagon-like peptide 1 (GLP-1) reduces appetite and food intake. In experimental models, GLP-1 has also been shown to play a role in thirst and drinking behavior. The aim of this trial was to investigate whether GLP-1 receptor agonists reduce fluid intake in patients with primary polydipsia.

中文翻译：

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GLP-1受体激动剂度拉鲁肽治疗原发性烦渴的随机对照试验

背景。以液体摄入过多为特征的原发性烦渴具有水中毒和低钠血症的风险，但治疗选择很少。胰高血糖素样肽 1 (GLP-1) 可降低食欲和食物摄入量。在实验模型中，GLP-1 也被证明在口渴和饮酒行为中发挥作用。本试验的目的是调查 GLP-1 受体激动剂是否会减少原发性烦渴患者的液体摄入量。