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Associations of Diet Quality with Midlife Brain Volume: Findings from the UK Biobank Cohort Study
Journal of Alzheimer’s Disease ( IF 4 ) Pub Date : 2021-09-01 , DOI: 10.3233/jad-210705
Helen Macpherson 1 , Sarah A McNaughton 1 , Karen E Lamb 2 , Catherine M Milte 1
Affiliation  

Background:Higher quality diets may be related to lower dementia rates. Midlife is emerging as a critical life stage for a number of dementia risk factors. Objective:This study examines whether diet quality is related to brain structure during midlife, and if this differs by sex. Methods:This studyused data from 19184 UK Biobank participants aged 40–65 years. Diet quality was assessed using three dietary indices including the Mediterranean Diet Score (MDS), Healthy Diet Score (HDS), and Recommended Food Score (RFS). MRI brain measures included total, grey, white and hippocampal volume. Linear regression examined associations between diet quality and brain volume, controlling for potential confounders. Results:Better quality diet across all indices was significantly related to larger grey matter volume: MDS β= 429.7 (95%CI: 65.2, 794.2); HDS β= 700.1 (348.0, 1052.1); and RFS β= 317.1 (106.8, 527.3). Higher diet scores were associated with greater total volume: HDS β= 879.32 (286.13, 1472.50); RFS β= 563.37 (209.10, 917.65); and white matter volume: RFS β= 246.31 (20.56, 472.05), with the exception of Mediterranean diet adherence. Healthy eating guidelines and dietary variety associations with total and grey matter volume were more prominent in men. Conclusion:Findings suggest that diet quality is associated with brain structure during midlife, potentially decades prior to the onset of dementia.

中文翻译:

饮食质量与中年脑容量的关联:来自英国生物银行队列研究的结果

背景:较高质量的饮食可能与较低的痴呆率有关。中年正在成为许多痴呆风险因素的关键生命阶段。目的:本研究检查饮食质量是否与中年的大脑结构有关,以及这是否因性别而异。方法:本研究使用了来自 19184 名年龄在 40-65 岁的英国生物银行参与者的数据。饮食质量使用三个饮食指数进行评估,包括地中海饮食评分 (MDS)、健康饮食评分 (HDS) 和推荐食物评分 (RFS)。MRI脑测量包括总体积、灰色、白色和海马体积。线性回归检查了饮食质量和脑容量之间的关联,控制了潜在的混杂因素。结果:所有指标的优质饮食与较大的灰质体积显着相关:MDS β= 429.7 (95%CI: 65.2, 794.2);HDS β = 700。1 (348.0, 1052.1); 和 RFS β = 317.1 (106.8, 527.3)。较高的饮食评分与较大的总体积相关:HDS β= 879.32 (286.13, 1472.50);RFS β= 563.37 (209.10, 917.65); 和白质体积:RFS β= 246.31 (20.56, 472.05),地中海饮食依从性除外。健康饮食指南和饮食种类与总体积和灰质体积的关联在男性中更为突出。结论:研究结果表明,饮食质量与中年期间的大脑结构相关,可能在痴呆发作前几十年。健康饮食指南和饮食种类与总体积和灰质体积的关联在男性中更为突出。结论:研究结果表明,饮食质量与中年期间的大脑结构相关,可能在痴呆发作前几十年。健康饮食指南和饮食种类与总体积和灰质体积的关联在男性中更为突出。结论:研究结果表明,饮食质量与中年期间的大脑结构相关,可能在痴呆发作前几十年。
更新日期:2021-09-03
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