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The separate and combined properties of the granular (area 29) and dysgranular (area 30) retrosplenial cortex
Neurobiology of Learning and Memory ( IF 2.7 ) Pub Date : 2021-09-03 , DOI: 10.1016/j.nlm.2021.107516
John P Aggleton 1 , Steliana Yanakieva 1 , Frank Sengpiel 2 , Andrew J Nelson 1
Affiliation  

Retrosplenial cortex contains two principal subdivisions, area 29 (granular) and area 30 (dysgranular). Their respective anatomical connections in the rat brain reveal that area 29 is the primary recipient of hippocampal and parahippocampal spatial and contextual information while area 30 is the primary interactor with current visual information. Lesion studies and measures of neuronal activity in rodents indicate that retrosplenial cortex helps to integrate space from different perspectives, e.g., egocentric and allocentric, providing landmark and heading cues for navigation and spatial learning. It provides a repository of scene information that, over time, becomes increasingly independent of the hippocampus. These processes, reflect the interactive actions between areas 29 and 30, along with their convergent influences on cortical and thalamic targets. Consequently, despite their differences, both areas 29 and 30 are necessary for an array of spatial and learning problems.



中文翻译:

颗粒状(29 区)和颗粒状(30 区)压后皮质的分离和组合特性

压后皮层包含两个主要细分,区域 29(颗粒)和区域 30(颗粒异常)。它们在大鼠大脑中各自的解剖学连接表明,区域 29 是海马和海马旁空间和上下文信息的主要接受者,而区域 30 是当前视觉信息的主要交互者。啮齿动物的损伤研究和神经元活动测量表明,压后皮层有助于从不同的角度整合空间,例如以自我为中心和以异能为中心,为导航和空间学习提供标志性和航向线索。它提供了一个场景信息库,随着时间的推移,这些信息库变得越来越独立于海马体。这些过程反映了区域 29 和 30 之间的交互作用,以及它们对皮质和丘脑目标的聚合影响。因此,尽管它们存在差异,但区域 29 和 30 对于一系列空间和学习问题都是必要的。

更新日期:2021-09-10
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