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Predictive values of tumor necrosis factor-α for depression treatment outcomes: effect modification by hazardous alcohol consumption
Translational Psychiatry ( IF 6.8 ) Pub Date : 2021-09-02 , DOI: 10.1038/s41398-021-01581-7
Wonsuk Choi 1 , Hee-Ju Kang 2 , Ju-Wan Kim 2 , Hee Kyung Kim 1 , Ho-Cheol Kang 1 , Ju-Yeon Lee 2 , Sung-Wan Kim 2 , Robert Stewart 3, 4 , Jae-Min Kim 2
Affiliation  

Inflammation is potentially associated with poor antidepressant treatment outcomes. Pro-inflammatory cytokines are influenced by hazardous alcohol consumption. The aim of the present study was to investigate the effects of the serum tumor necrosis factor-α (sTNF-α) level on antidepressant treatment outcomes in terms of the 12-week and 12-month remission rates and 24-month relapse rate, and to investigate the potential modifying effects of alcohol consumption on these associations in patients with depressive disorders. At baseline, sTNF-α was measured and alcohol-related data from the Alcohol Use Disorders Identification Test (AUDIT) and consumption history were collected from 1094 patients. Patients received stepwise antidepressant treatment. Remission at 12 weeks and 12 months was defined as a Hamilton Depression Rating Scale (HAMD) score ≤ 7. Relapse (HAMD score ≥ 14) was identified until 24 months for those who had initially responded (HAMD score <14) at 12 weeks. Higher sTNF-α levels were found to have significant effects on the 12-week and 12-month non-remission and 24-month relapse rates. These effects were more prominent in those with low levels of alcohol consumption (AUDIT score ≤ 8 or no current alcohol consumption); the effects were not significant in those exhibiting hazardous alcohol consumption (AUDIT score > 8 or current drinking). Significant interactions were found for the 12-month non-remission and relapse rates, although the interaction was not statistically significant for 12-week remission. In conclusion, baseline sTNF-α levels may be a useful predictor for both short- and long-term antidepressant treatment outcomes, and the consideration of alcohol consumption status may increase predictability, in particular for long-term outcomes.



中文翻译:

肿瘤坏死因子-α对抑郁症治疗结果的预测价值:有害饮酒对效果的影响

炎症可能与抗抑郁药治疗效果不佳有关。促炎细胞因子受有害饮酒的影响。本研究的目的是调查血清肿瘤坏死因子-α(sTNF-α)水平对抗抑郁治疗结果的影响,包括 12 周和 12 个月的缓解率和 24 个月的复发率,以及研究饮酒对抑郁症患者这些关联的潜在改变作用。在基线时,测量了 sTNF-α,并从 1094 名患者中收集了来自酒精使用障碍识别测试 (AUDIT) 和消费历史的酒精相关数据。患者接受逐步抗抑郁治疗。12 周和 12 个月的缓解定义为汉密尔顿抑郁量表 (HAMD) 评分≤7。对于那些在 12 周时最初有反应(HAMD 评分 <14)的人,在 24 个月内确定复发(HAMD 评分 ≥ 14)。发现较高的 sTNF-α 水平对 12 周和 12 个月的非缓解率和 24 个月的复发率有显着影响。这些影响在饮酒量低的人群中更为显着(AUDIT 评分 ≤ 8 或当前没有饮酒);对于那些表现出危险饮酒(AUDIT 评分 > 8 或当前饮酒)的人,这种影响并不显着。发现 12 个月的非缓解率和复发率存在显着的相互作用,尽管 12 周缓解的相互作用没有统计学意义。总之,基线 sTNF-α 水平可能是短期和长期抗抑郁治疗结果的有用预测指标,

更新日期:2021-09-03
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