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Herbal Medicines in the Treatment of Dyspepsia: An Overview
Planta Medica ( IF 2.7 ) Pub Date : 2021-09-02 , DOI: 10.1055/a-1580-7782
Thaise Boeing 1 , Priscila de Souza 1 , Luisa Mota da Silva 1 , Arquimedes Gasparotto Junior 2
Affiliation  

This review focuses on the efficacy of herbal medicines for managing dyspepsia in humans and animals. Searches were conducted on the PubMed, Science Direct, and Medline databases, for publications in the last 3 years. In each database, the search terms used consisted of the 2 key terms describing the disorder and subtypes plus each of the terms relating to the therapy. The key terms used were “natural product” and “medicinal plant” in a cross-over with “dyspepsia” and “functional dyspepsia” (i.e., gastroprotection, Helicobacter pylori infection, prokinetic). We included all human and animal studies on the effects of herbal medicines reporting the key outcome of dyspepsia symptoms. Preclinical studies using critically validated models showed that most medicinal plants with gastroprotective action had antioxidant, anti-inflammatory, anti-apoptotic, and antisecretory effects. Moreover, several species displayed anti Helicobacter pylori and prokinetic efficacy. The data availability of controlled clinical studies is currently minimal. The use of different methodologies and the minimal number of patients raise doubts about the effects of these preparations. Only adequate clinical trials with scientifically validated methods can determine whether different herbal medicines can be used as viable alternatives to the conventional pharmacological treatments used to control dyspepsia symptoms.

中文翻译:

治疗消化不良的草药:概述

本综述侧重于草药治疗人类和动物消化不良的疗效。检索了 PubMed、Science Direct 和 Medline 数据库,以查找过去 3 年的出版物。在每个数据库中,使用的搜索词包括描述疾病和亚型的 2 个关键术语以及与治疗相关的每个术语。使用的关键术语是“天然产物”和“药用植物”,与“消化不良”和“功能性消化不良”(即胃保护、幽门螺杆菌感染、促动力)交叉。我们纳入了所有关于报告消化不良症状关键结果的草药效果的人类和动物研究。使用经过严格验证的模型进行的临床前研究表明,大多数具有胃保护作用的药用植物具有抗氧化、抗炎、抗凋亡、和抗分泌作用。此外,一些物种表现出抗幽门螺杆菌和促动力功效。对照临床研究的数据可用性目前很少。使用不同的方法和最少的患者数量引起了对这些制剂效果的怀疑。只有采用经过科学验证的方法进行充分的临床试验才能确定不同的草药是否可以作为用于控制消化不良症状的常规药物治疗的可行替代品。
更新日期:2021-09-03
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