DNA hydrogels have received considerable attention in various promising applications due to their excellent biocompatibility, controlled biodegradability, adjustable mechanical properties, stability against proteases, self-healing ability, and stimuli responsiveness. To obtain the specific molecular recognition capability, aptamers and many other functional motifs are utilized. Aptamers are short single-stranded DNA or RNA selected through SELEX to bind with specific target with high affinity and specificity. With advantages of broad range of targets, good stability, easy modification, and low cost, aptamer functionalized DNA hydrogels become popular in a wide range of promising applications. In this review, the recent progress on aptamer functionalized DNA hydrogels including general design principles, applications and kinetics has been summarized. Finally, the current challenges and prospects are discussed.

DNA水凝胶由于其优异的生物相容性、可控的生物降解性、可调节的机械性能、对蛋白酶的稳定性、自愈能力和刺激响应性，在各种有前途的应用中受到了相当大的关注。为了获得特定的分子识别能力，使用了适体和许多其他功能基序。适体是通过 SELEX 选择的短单链 DNA 或 RNA，以高亲和力和特异性与特定靶标结合。适体功能化的 DNA 水凝胶具有靶标范围广、稳定性好、易于修饰和成本低等优点，在广泛的有前景的应用中广受欢迎。在这篇综述中，适体功能化 DNA 水凝胶的最新进展包括一般设计原则，应用和动力学进行了总结。最后，讨论了当前的挑战和前景。