Key Message

The hypothesis has been suggested that viral infections are related to the pathogenesis of bipolar disorder. COVID-19 infection could trigger an initial manic episode, which rapidly improves following treatment with atypical antipsychotics. Prolonged treatment needs to be considered even after the early remission as with typical manic episodes. Maintenance treatment for mood stabilization should be considered and further investigated if there are differential pharmacological outcomes compared with typical manic episodes.

Learning Points

• Manic or hypomanic episodes can present following a symptomatic COVID-19 infection even in a previously naïve patient.
• The antipsychotics which have been effective for manic episodes seem to be effective for a manic episode occurring in relation to COVID-19 infection as well regardless of the medical treatment provided for the COVID-19 infection.

中文翻译：

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COVID-19 感染后的第一次躁狂发作

关键信息

该假设已提出病毒感染与双相情感障碍的发病机制有关。COVID-19 感染可能引发最初的躁狂发作，在用非典型抗精神病药物治疗后迅速改善。即使在早期缓解后也需要考虑延长治疗，就像典型的躁狂发作一样。如果与典型躁狂发作相比存在不同的药理结果，则应考虑并进一步研究用于情绪稳定的维持治疗。

学习点

• 有症状的 COVID-19 感染后可能会出现躁狂或轻躁狂发作，即使是以前幼稚的患者也是如此。
• 对躁狂发作有效的抗精神病药物似乎对与 COVID-19 感染有关的躁狂发作也有效，无论为 COVID-19 感染提供何种药物治疗。