Using principal component analysis to examine associations of early pregnancy inflammatory biomarker profiles and adverse birth outcomes,American Journal of Reproductive Immunology

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Using principal component analysis to examine associations of early pregnancy inflammatory biomarker profiles and adverse birth outcomes
American Journal of Reproductive Immunology ( IF 3.6 ) Pub Date : 2021-09-03 , DOI: 10.1111/aji.13497
Lauren S Keenan-Devlin _{1,

2} , Madeleine Caplan _{1,

3} , Alexa Freedman _{1,

4,

5} , Kristine Kuchta ₆ , William Grobman _{7,

8} , Claudia Buss _{9,

10} , Emma K Adam _{5,

11} , Sonja Entringer _{9,

10} , Gregory E Miller _{4,

5} , Ann E B Borders _{1,

2,

8}

Affiliation

Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, Illinois, USA.
University of Chicago Pritzker School of Medicine, Chicago, Illinois, USA.
Duke University School of Medicine, Durham, North Carolina, USA.
Department of Psychology, Northwestern University, Evanston, Illinois, USA.
Institute for Policy Research, Northwestern University, Evanston, Illinois, USA.
Center for Biomedical Research Informatics, NorthShore University HealthSystem, Evanston, Illinois, USA.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Institute for Public Health and Medicine, Center for Healthcare Studies, Northwestern University, Chicago, Illinois, USA.
Development, Health and Disease Research Program, University of California Irvine, Irvine, California, USA.
Department of Medical Psychology, Charité, University Medicine Berlin, Berlin, Germany.
School of Education and Social Policy, Northwestern University, Evanston, Illinois, USA.

Inflammation as a risk factor for preterm birth is well-established. The primary objective of this analysis was to examine whether individual cytokines versus a composite indicator of mid-pregnancy inflammation are significantly associated with risk for adverse birth outcomes.

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