Abstract

Context

IGF-I is important for postnatal growth and may be of diagnostic value in infants suspected of pituitary disease; however, little is known about the impact of IGF-I and its determinants on infant growth. Importantly, detailed reference ranges for IGF-I and IGF binding protein-3 (IGFBP-3) concentrations during infancy are lacking.

Objective

To evaluate the rapid changes in weight and length as well as their determinants in healthy infants, and to establish age- and sex-specific reference curves for IGF-I and IGFBP-3 in children aged 0 to 1 years.

Design

Prospective longitudinal study.

Setting

Cohort study.

Participants

A total of 233 healthy children (114 girls) with repeated blood samples during the first year of life.

Main Outcome Measure(s)

Serum concentrations of IGF-I and IGFBP-3, length velocity, weight velocity, and PAPPA2 (rs1325598) genotype.

Results

Individual trajectories of length and weight velocities were sex specific. We provide detailed reference curves based on longitudinal data for IGF-I and IGFBP-3 during infancy. In both girls and boys, IGF-I decreased during infancy, whereas IGFBP-3 remained stable. IGF-I and IGFBP-3, but not PAPPA2 genotype, were positively associated with weight gain, but not with longitudinal growth. When stratified by sex, the association between weight gain and IGF-I only remained significant in girls.

Conclusions

Interestingly, we found a significant association between IGF-I and infant weight gain in girls, but not with longitudinal growth in the first year of life. Our findings highlight the role of IGF-I as an important anabolic hormone that is not limited to linear growth.

中文翻译：

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婴儿期血清 IGF-I 和生长的动态变化：与体脂、目标身高和 PAPPA2 基因型的关联

摘要

语境

IGF-I 对产后生长很重要，可能对疑似垂体疾病的婴儿具有诊断价值；然而，关于 IGF-I 及其对婴儿生长的决定因素的影响知​​之甚少。重要的是，缺乏婴儿期 IGF-I 和 IGF 结合蛋白 3 (IGFBP-3) 浓度的详细参考范围。

客观的

评估健康婴儿体重和身长的快速变化及其决定因素，并建立 0 至 1 岁儿童 IGF-I 和 IGFBP-3 的年龄和性别特异性参考曲线。

设计

前瞻性纵向研究。

环境

队列研究。

参与者

共有 233 名健康儿童（114 名女孩）在生命的第一年重复采集了血液样本。

主要观察指标）

IGF-I 和 IGFBP-3 的血清浓度、长度速度、体重速度和PAPPA2 (rs1325598) 基因型。

结果

长度和体重速度的个体轨迹具有性别特异性。我们根据婴儿期 IGF-I 和 IGFBP-3 的纵向数据提供详细的参考曲线。在女孩和男孩中，婴儿期 IGF-I 下降，而 IGFBP-3 保持稳定。IGF-I 和 IGFBP-3，但不是PAPPA2基因型，与体重增加呈正相关，但与纵向生长无关。当按性别分层时，体重增加与 IGF-I 之间的关联仅在女孩中仍然显着。

结论

有趣的是，我们发现 IGF-I 与女孩婴儿体重增加之间存在显着关联，但与出生后第一年的纵向增长无关。我们的研究结果强调了 IGF-I 作为一种重要的合成代谢激素的作用，不仅限于线性生长。