当前位置: X-MOL 学术J. Clin. Endocrinol. Metab. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes
The Journal of Clinical Endocrinology & Metabolism ( IF 5.8 ) Pub Date : 2021-09-02 , DOI: 10.1210/clinem/dgab649
Neda Rasouli 1 , Irwin G Brodsky 2 , Ranee Chatterjee 3 , Sun H Kim 4 , Richard E Pratley 5 , Myrlene A Staten 6 , Anastassios G Pittas 7
Affiliation  

Abstract
Context
Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on β-cell function remain unclear.
Objective
To investigate the effects of vitamin D3 supplementation on insulin sensitivity and β-cell function.
Methods
This is a prespecified secondary analysis of the Vitamin D and Type 2 Diabetes study. Overweight/obese adults at high risk for type 2 diabetes (prediabetes) were randomly treated with vitamin D3 4000 IU or matching placebo daily for 24 months.
Main Outcome
Disposition index (DI), as an estimate of β-cell function, was calculated as the product of Homeostasis Model Assessment 2 indices derived from C-peptide values (HOMA2%Scpep) and C-peptide response during the first 30 minutes of a 75-g oral glucose tolerance test (OGTT).
Results
Mean age was 60.5 ± 9.8 years and body mass index was 31.9 ± 4.4 kg/m2. Mean serum 25(OH)D level increased from 27.9 ± 10.3 ng/mL at baseline to 54.9 ng/mL at 2 years in the vitamin D group and was unchanged (28.5 ± 10.0 ng/mL) in the placebo group. The baseline DI predicted incident diabetes independent of the intervention. In the entire cohort, there were no significant differences in changes in DI, HOMA2%Scpep, or C-peptide response between the 2 groups. Among participants with baseline 25(OH)D level <12 ng/mL, the mean percent differences for DI between the vitamin D and placebo groups was 8.5 (95% CI, 0.2-16.8).
Conclusions
Supplementation with vitamin D3 for 24 months did not improve an OGTT-derived index of β-cell function in people with prediabetes not selected based on baseline vitamin D status; however, there was benefit among those with very low baseline vitamin D status.


中文翻译:

补充维生素 D 对前驱糖尿病患者胰岛素敏感性和分泌的影响

摘要
语境
维生素 D 调节葡萄糖稳态途径,但补充维生素 D 对 β 细胞功能的影响仍不清楚。
客观的
研究补充维生素 D 3对胰岛素敏感性和 β 细胞功能的影响。
方法
这是对维生素 D 和 2 型糖尿病研究的预先指定的二次分析。患有 2 型糖尿病(前驱糖尿病)高风险的超重/肥胖成人每天随机接受维生素 D 3 4000 IU 或匹配安慰剂治疗,持续 24 个月。
主要成果
处置指数 (DI) 作为 β 细胞功能的估计值,计算为稳态模型评估 2 指数的乘积,该指数源自 C 肽值 (HOMA2%S cpep ) 和前 30 分钟内的 C 肽反应75克口服葡萄糖耐量试验(OGTT)。
结果
平均年龄为 60.5 ± 9.8 岁,体重指数为 31.9 ± 4.4 kg/m 2。维生素 D 组的平均血清 25(OH)D 水平从基线时的 27.9 ± 10.3 ng/mL 增加到 2 年时的 54.9 ng/mL,而安慰剂组没有变化 (28.5 ± 10.0 ng/mL)。基线 DI 预测独立于干预的糖尿病事件。在整个队列中,两组之间的 DI、HOMA2%S cpep或 C 肽反应的变化没有显着差异。在基线 25(OH)D 水平 <12 ng/mL 的参与者中,维生素 D 组和安慰剂组之间 DI 的平均百分比差异为 8.5(95% CI,0.2-16.8)。
结论
补充维生素 D 3 24 个月并没有改善未根据基线维生素 D 状态选择的前驱糖尿病患者的 OGTT 衍生的 β 细胞功能指数;然而,基线维生素 D 状态非常低的人有益处。
更新日期:2021-09-02
down
wechat
bug