Chalcogen bonds are the specific interactions involving group 16 elements as electrophilic sites. The role of chalcogen atoms as sticky sites in biomolecules is underappreciated, and the few available studies have mostly focused on S. Here, we carried out a statistical analysis over 3562 protein structures in the Protein Data Bank (PDB) containing 18 266 selenomethionines and found that Se···O chalcogen bonds are commonplace. These findings may help the future design of functional peptides and contribute to understanding the role of Se in nature.

中文翻译：

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蛋白质结构中涉及硒的硫族键

硫属键是涉及 16 族元素作为亲电位点的特定相互作用。硫族原子作为生物分子中粘性位点的作用未被充分认识，现有的少数研究主要集中在 S。在这里，我们对蛋白质数据库 (PDB) 中包含 18 266 个硒代蛋氨酸的 3562 个蛋白质结构进行了统计分析，发现Se·O硫属键很常见。这些发现可能有助于未来功能性肽的设计，并有助于了解硒在自然界中的作用。