Frontiers in Life Science ( IF 1.333 ) Pub Date : 2021-09-03 , DOI: 10.1080/26895293.2021.1972350 Shishi Ming 1 , Dianlong Zhang 1 , Long Chen 1 , Yuan Shi 1
To determine association of severe anemia and red blood cell (RBC) transfusions with bronchopulmonary dysplasia (BPD) in preterm infants with gestational age<32 weeks, a retrospective analysis was conducted on 364 newborns from August 1,2018, until August 31,2020. 135 patients were diagnosed with BPD and the other 229 neonates were included in the non-BPD group. One-to-one propensity score matching (83:83) was used to match the baseline characteristics and confounding factors of patients so as to better evaluate effects of anemia and RBC transfusion. The results showed that the rate of severe anemia was significantly different between the BPD group and non-BPD group [14/83(16.87) vs 4/83(4.82), p = 0.013]. The number and volume of transfusion were significantly lower in the non-BPD group than in the BPD group [number:1(0,2) vs 2(0,4), p = 0.001;volume:30(0,40) vs 40(20,80), p = 0.004]. We find that Among anemic neonates,only severe anemia may increase the risk of developing BPD. Larger volume and higher number of RBC transfusions are related to BPD and its severity. Risk of BPD was neither related to the onset of anemia nor the timing of first transfusion. Medical methods should be adopted to prevent severe anemia and reduce RBC transfusions.
Registration Name of registry: Chinese Clinical Trial Registry, Registry number: ChiCTR 2100042768. Registration date: 28 January, 2021. URL of the trial in the registry database:http://www.chictr.org.cn/listbycreater.aspx.
中文翻译:
早产儿贫血和红细胞输注对支气管肺发育不良发展的影响:倾向评分分析
为了确定胎龄<32周早产儿严重贫血和红细胞输注与支气管肺发育不良(BPD)的关系,对2018年8月1日至2020年8月31日的364名新生儿进行了回顾性分析。135 名患者被诊断为 BPD,其他 229 名新生儿被纳入非 BPD 组。使用一对一倾向评分匹配(83:83)匹配患者的基线特征和混杂因素,以更好地评估贫血和红细胞输注的效果。结果显示BPD组与非BPD组严重贫血发生率有显着差异[14/83(16.87) vs 4/83(4.82), p = 0.013]。非 BPD 组的输血次数和体积显着低于 BPD 组 [数量:1(0,2) vs 2(0,4),p = 0.001;体积:30(0,40) vs 40(20,80), p = 0.004]。我们发现在贫血新生儿中,只有严重贫血才可能增加患 BPD 的风险。更大的容量和更多的 RBC 输血与 BPD 及其严重程度有关。BPD 的风险与贫血的发生和首次输血的时间无关。应采取医学方法预防严重贫血,减少红细胞输注。
注册名称:Chinese Clinical Trial Registry,注册号:ChiCTR 2100042768。注册日期:2021年1月28日。注册数据库中的试验网址:http://www.chictr.org.cn/listbycreater.aspx。