In this issue of Cell Stem Cell, Tallapragada et al. (2021) present an intestinal organoid culture system for high-throughput live imaging to investigate niche-independent mechanisms of crypt fission. They find that Piezo activity downregulates Lgr5 expression in stretched epithelial cells within inflated organoids, which form multiple new crypts upon collapse.

中文翻译：

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通货膨胀在秋天来临之前：上皮拉伸如何驱动隐窝裂变

在本期《细胞干细胞》中，Tallapragada 等人。(2021) 提出了一种用于高通量实时成像的肠道类器官培养系统，以研究隐窝裂变的利基独立机制。他们发现压电活性下调了膨胀类器官内拉伸上皮细胞中 Lgr5 的表达，这些细胞在塌陷时形成多个新的隐窝。