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Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma
Environmental Toxicology ( IF 4.5 ) Pub Date : 2021-09-02 , DOI: 10.1002/tox.23359
Gopalakrishnan Balaraman 1 , Jagan Sundaram 1 , Ashok Mari 1 , Palanisamy Krishnan 1 , Sharmila Salam 1 , Nirmala Subramaniam 1 , Immaduddin Sirajduddin 1 , Devaki Thiruvengadam 1
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Hepatocellular carcinoma is a well-known internal malignancy with increased worldwide mortality. The increased progression rate is closely associated with chronic liver diseases such as cirrhosis. Chemical carcinogens cause tumor advocacy over free radical metabolites to causes numerous biochemical and molecular changes that bring oxidative stress. In addition, inflammatory cells and its growth factor promotes the progression of liver cancer through deregulates the numerous cellular signaling pathways involved in normal cellular proliferation. Plant derived phytochemicals have a better complimentary potency to defend against a wide array of free radical mediated diseases such as cancer. More recently, we have evaluated the anticancer effect of Farnesol against DEN induced hepatocellular carcinoma in male wistar albino rats. However, the possible mechanism in which Farnesol attributes its anticancer effect against DEN induced liver cancer remains unknown. Hence in the present study, an attempt has been made to reduce the oxidative stress by appraise the antioxidant effect by Farnesol in DEN induced hepatocellular carcinoma. Elevated oxidative stress markers with concomitant decreased cellular antioxidants levels were observed in DEN induced hepatic tissues. Further, proliferating nuclei with increased proliferating cell nucleolar antigen (PCNA) and inflammatory mediator expression were observed in DEN induced rats. Oral supplementation of Farnesol to DEN induced rats significantly decrease the oxidative stress markers and increase the cellular antioxidant status. Moreover, Farnesol treatment decreases the argyrophilic nuclear organizer region and PCNA along with decreased expression of inflammatory mediators suggest that Farnesol treatment restores DEN induced hepatic abnormalities and protects liver from cancer progression.

中文翻译:

Farnesol减轻二乙基亚硝胺诱导的炎症并保护实验性大鼠肝细胞癌

肝细胞癌是一种众所周知的内部恶性肿瘤,在全球范围内死亡率增加。进展速度的增加与肝硬化等慢性肝病密切相关。化学致癌物引起肿瘤对自由基代谢物的宣传,从而引起许多生化和分子变化,从而带来氧化应激。此外,炎症细胞及其生长因子通过解除对参与正常细胞增殖的众多细胞信号通路的调节来促进肝癌的进展。植物来源的植物化学物质具有更好的补充效力,可以抵御多种自由基介导的疾病,例如癌症。最近,我们在雄性 wistar 白化大鼠中评估了 Farnesol 对 DEN 诱导的肝细胞癌的抗癌作用。然而,Farnesol 将其抗癌作用归因于 DEN 诱导的肝癌的可能机制尚不清楚。因此,在本研究中,已尝试通过评估 Farnesol 在 DEN 诱导的肝细胞癌中的抗氧化作用来减少氧化应激。在 DEN 诱导的肝组织中观察到氧化应激标志物升高,同时细胞抗氧化剂水平降低。此外,在 DEN 诱导的大鼠中观察到增殖细胞核具有增加的增殖细胞核仁抗原 (PCNA) 和炎症介质表达。对 DEN 诱导的大鼠口服法尼醇可显着降低氧化应激标志物并增加细胞抗氧化状态。而且,
更新日期:2021-11-03
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