The rapid fabrication of artificial skin patches with multiple functions has attracted great attention in various research fields, such as personal health monitoring, tissue engineering and robotics. Intertwined-network structures (blood vessel, lymphatic and nerve networks) play a key role in endowing skin with multiple functions. Thus, considerable efforts have been devoted to fabricating artificial skin patches with mimetic internal channels. Here, we present a one-step 3D printed intelligent silk fibroin artificial skin (i-skin) with built-in electronics and microfluidics. By simultaneously extruding functional materials in polyurethane-silk fibroin precursor using a 3D bioprinter, the i-skin and its internal channels can be fabricated within one step. Photonic crystals (PCs) were integrated into the microfluidic channel, enabling the i-skin to sense multiple biomarkers. Moreover, the printed electronics give the i-skin remarkable conductivity, endowing the i-skin with the capability of sensitive motion sensing. Notably, by using the built-in electronics and PC-integrated microfluidics, sensitive sensing of motions and specific cardiac biomarkers can be achieved simultaneously in the i-skin, indicating the remarkable prospects of the printed multi-functional i-skin in health care-related biomedical fields.

中文翻译：

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内置电子和微流体的一步式 3D 打印智能丝素蛋白人造皮肤

多功能人造皮肤贴片的快速制备在个人健康监测、组织工程和机器人等各个研究领域引起了极大的关注。交织的网络结构（血管、淋巴和神经网络）在赋予皮肤多种功能方面发挥着关键作用。因此，大量的努力致力于制造具有模拟内部通道的人造皮肤贴片。在这里，我们展示了一种内置电子设备和微流体的一步式 3D 打印智能丝素蛋白人造皮肤（i-skin）。通过使用 3D 生物打印机同时挤出聚氨酯-丝素蛋白前体中的功能材料，i-skin 及其内部通道可以在一个步骤中制造出来。光子晶体 (PC) 被集成到微流体通道中，使 i-skin 能够感知多种生物标志物。此外，印刷电子器件赋予 i-skin 显着的导电性，赋予 i-skin 灵敏的运动感应能力。值得注意的是，通过使用内置的电子设备和 PC 集成的微流体，i-skin 可以同时实现对运动的灵敏感知和特定的心脏生物标志物，这表明印刷多功能 i-skin 在医疗保健方面的前景可观。相关生物医学领域。