Vassos et al¹ “failed to confirm the findings of Ursini et al.²” There are a number of critical issues in comparing the 2 studies and in potentially explaining the inconsistencies. Here, we will stress only our concerns about the validity of their documentation of Early Life Complications (ELCs), overlooking other issues related to the broader definition of psychosis of Vassos et al¹ and their inclusion of a sample with only 17 controls. In their largest sample, the UK Biobank (UKB), birth weight was their sole proxy for ELCs. Many ELCs associated with schizophrenia risk do not affect birth weight. In the Cardiff sample, the ELC data came from patient interviews, a questionable source.

中文翻译：

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复制G×E：魔鬼与细节

Vassos 等人¹ “未能证实 Ursini 等人的发现。² ”在比较这两项研究并可能解释不一致之处时，存在许多关键问题。在这里，我们将仅强调我们对其早期生活并发症 (ELC) 文档有效性的担忧，忽略与 Vassos 等人¹的更广泛的精神病定义相关的其他问题，以及他们仅包含 17 个对照的样本。在他们最大的样本英国生物银行 (UKB) 中，出生体重是 ELC 的唯一代表。许多与精神分裂症风险相关的 ELC 不影响出生体重。在加的夫样本中，ELC 数据来自患者访谈，这是一个有问题的来源。