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Extended Frontal Networks for Visual and Auditory Working Memory
Cerebral Cortex ( IF 3.7 ) Pub Date : 2021-07-02 , DOI: 10.1093/cercor/bhab249
Abigail L Noyce 1, 2 , Ray W Lefco 3 , James A Brissenden 2, 4 , Sean M Tobyne 3 , Barbara G Shinn-Cunningham 1 , David C Somers 2
Affiliation  

Working memory (WM) supports the persistent representation of transient sensory information. Visual and auditory stimuli place different demands on WM and recruit different brain networks. Separate auditory- and visual-biased WM networks extend into the frontal lobes, but several challenges confront attempts to parcellate human frontal cortex, including fine-grained organization and between-subject variability. Here, we use differential intrinsic functional connectivity from 2 visual-biased and 2 auditory-biased frontal structures to identify additional candidate sensory-biased regions in frontal cortex. We then examine direct contrasts of task functional magnetic resonance imaging during visual versus auditory 2-back WM to validate those candidate regions. Three visual-biased and 5 auditory-biased regions are robustly activated bilaterally in the frontal lobes of individual subjects (N = 14, 7 women). These regions exhibit a sensory preference during passive exposure to task stimuli, and that preference is stronger during WM. Hierarchical clustering analysis of intrinsic connectivity among novel and previously identified bilateral sensory-biased regions confirms that they functionally segregate into visual and auditory networks, even though the networks are anatomically interdigitated. We also observe that the frontotemporal auditory WM network is highly selective and exhibits strong functional connectivity to structures serving non-WM functions, while the frontoparietal visual WM network hierarchically merges into the multiple-demand cognitive system.

中文翻译:

视觉和听觉工作记忆的扩展额叶网络

工作记忆 (WM) 支持瞬态感觉信息的持久表示。视觉和听觉刺激对 WM 提出不同的要求并招募不同的大脑网络。独立的听觉和视觉偏差 WM 网络延伸到额叶,但分割人类额叶皮层的尝试面临一些挑战,包括细粒度组织和受试者间变异性。在这里,我们使用来自 2 个视觉偏向和 2 个听觉偏向额叶结构的差异内在功能连接来识别额叶皮层中额外的候选感觉偏向区域。然后,我们检查视觉与听觉 2-back WM 期间任务功能磁共振成像的直接对比,以验证这些候选区域。三个视觉偏向和 5 个听觉偏向区域在个体受试者的额叶中被双侧强烈激活(N = 14,7 名女性)。这些区域在被动暴露于任务刺激期间表现出感官偏好,并且这种偏好在 WM 期间更强。对新的和先前确定的双侧感觉偏向区域之间的内在连通性进行的层次聚类分析证实,它们在功能上分离成视觉和听觉网络,即使这些网络在解剖学上是相互交叉的。我们还观察到额颞听觉 WM 网络具有高度选择性,并表现出与服务于非 WM 功能的结构的强大功能连接,而额顶视觉 WM 网络分层合并到多需求认知系统中。7 名女性)。这些区域在被动暴露于任务刺激期间表现出感官偏好,并且这种偏好在 WM 期间更强。对新的和先前确定的双侧感觉偏向区域之间的内在连通性进行的层次聚类分析证实,它们在功能上分离成视觉和听觉网络,即使这些网络在解剖学上是相互交叉的。我们还观察到额颞听觉 WM 网络具有高度选择性,并表现出与服务于非 WM 功能的结构的强大功能连接,而额顶视觉 WM 网络分层合并到多需求认知系统中。7 名女性)。这些区域在被动暴露于任务刺激期间表现出感官偏好,并且这种偏好在 WM 期间更强。对新的和先前确定的双侧感觉偏向区域之间的内在连通性进行的层次聚类分析证实,它们在功能上分离成视觉和听觉网络,即使这些网络在解剖学上是相互交叉的。我们还观察到额颞听觉 WM 网络具有高度选择性,并表现出与服务于非 WM 功能的结构的强大功能连接,而额顶视觉 WM 网络分层合并到多需求认知系统中。对新的和先前确定的双侧感觉偏向区域之间的内在连通性进行的层次聚类分析证实,它们在功能上分离成视觉和听觉网络,即使这些网络在解剖学上是相互交叉的。我们还观察到额颞听觉 WM 网络具有高度选择性,并表现出与服务于非 WM 功能的结构的强大功能连接,而额顶视觉 WM 网络分层合并到多需求认知系统中。对新的和先前确定的双侧感觉偏向区域之间的内在连通性进行的层次聚类分析证实,它们在功能上分离成视觉和听觉网络,即使这些网络在解剖学上是相互交叉的。我们还观察到额颞听觉 WM 网络具有高度选择性,并表现出与服务于非 WM 功能的结构的强大功能连接,而额顶视觉 WM 网络分层合并到多需求认知系统中。
更新日期:2021-07-02
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