We appreciate the interest shown by J.F.M. van Boven and co-workers in our study. PACT [1] was first and foremost designed as a pragmatic randomised controlled trial (RCT) reflecting current UK primary care practice. While addition of controller treatment for those in the personalised care group with poor control was guided by the study algorithm, the decisions with respect to monotherapy versus combination therapy, inhaler type and use of a spacer was down to the discretion of the participant's primary care team.

中文翻译：

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青少年哮喘现实生活中实用临床试验的思考

我们感谢 JFM van Boven 和同事对我们的研究表现出的兴趣。PACT [1] 最初是作为一项实用的随机对照试验 (RCT) 设计的，反映了当前英国的初级保健实践。虽然在研究算法指导下为个性化护理组中控制不佳的患者添加控制治疗，但关于单一疗法与联合疗法、吸入器类型和使用间隔器的决定取决于参与者的初级保健团队的判断.