The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism.

分子伴侣 FK506 结合蛋白 51 (FKBP51) 作为代谢功能障碍的有意义的生物标志物而受到关注。本综述探讨了 FKBP51 在脂肪生成和脂质代谢、肌生成和蛋白质分解代谢以及糖皮质激素诱导的皮肤发育不全和真皮脂肪细胞中的新贡献。讨论了可以解释这些代谢后果的 FKBP51 信号传导机制。这些机制是多种多样的，FKBP51 独立并直接调节磷酸化级联和核受体。我们讨论了新开发的拮抗 FKBP51 的化合物，这可能为肥胖症提供治疗优势。这些观察表明我们才刚刚开始揭示 FKBP51 的复杂性质及其代谢的分子伴侣。