Nuclear receptors (NRs) are ligand-binding transcription factors that regulate gene networks and physiological responses. Often oxidative stress precedes the onset of liver diseases, and Nrf2 is a key regulator of antioxidant pathways. NRs crosstalk with Nrf2, since NR activation can influence the oxidative milieu by modulating reductive cellular processes. Diet and xenobiotics also regulate NR expression and activity, suggesting a feedback loop. Depending on the tissue context and cues, NRs either increase or decrease toxicity and oxidative damage. Many FDA-approved drugs target NRs, and one could potentially repurpose them to ameliorate reactive oxygen species (ROS). Here, we discuss how several NRs modulate oxidative stress subsequent to diet, organic pollutants, and drug-induced injury to the liver.

核受体 (NRs) 是调节基因网络和生理反应的配体结合转录因子。氧化应激通常先于肝脏疾病的发作，而 Nrf2 是抗氧化途径的关键调节因子。NRs 与 Nrf2 串扰，因为 NR 激活可以通过调节还原性细胞过程来影响氧化环境。饮食和异生素也调节 NR 的表达和活性，表明存在反馈循环。根据组织环境和线索，NRs 会增加或减少毒性和氧化损伤。许多 FDA 批准的药物都针对 NR，其中一种可能会重新利用它们来改善活性氧 (ROS)。在这里，我们讨论了几种 NRs 如何调节饮食、有机污染物和药物引起的肝脏损伤后的氧化应激。