α-Amanitin is a highly toxic peptide widely found in species of poisonous mushrooms. The matrix effect has been a major obstacle for accurate determination of α-amanitin in plasma samples by liquid chromatography/tandem mass spectrometry (LC/MS/MS). In this study, the strategy to eliminate the matrix effect of α-amanitin with a one-step dilution approach after deproteinization was applied.

中文翻译：

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一种简单可靠的大鼠血浆中α-鹅膏菌素检测方法的开发及其在毒代动力学研究中的应用

α-鹅膏菌素是一种剧毒肽，广泛存在于各种毒蘑菇中。基质效应一直是液相色谱/串联质谱 (LC/MS/MS) 准确测定血浆样品中 α-鹅膏菌素的主要障碍。在本研究中，应用了在脱蛋白后通过一步稀释法消除 α-鹅膏菌素基质效应的策略。