Abstract

A novel pH-responsive magnetic nanosystem was designed and developed for cancer therapy. For this purpose, a well-defined terpolymer was synthesized through the polymerization of 2-hydroxyethyl methacrylate (HEMA) monomer using reversible addition fragmentation chain transfer (RAFT) technique and simultaneous grafting of ε-caprolactone (ε-CL) monomer via ring-opening polymerization (ROP) approach followed by block copolymerization of acrylic acid (AA) monomer via RAFT polymerization method, in order to produce a poly(acrylic acid)-block-[poly(2-oxyethyl methacrylate)-grafted-poly(ε-caprolactone)] [PAA-b-(POEMA-g-PCL)]. Afterward, magnetite nanoparticles (Fe₃O₄ NPs) were synthesized through chemical co-precipitation method, and then incorporated into the developed terpolymer through physical interactions (e.g., electrostatic and hydrogen bonding) via solution mixing approach. The doxorubicin hydrochloride (Dox), as an anticancer model drug, loading (LE) and encapsulation (EE) efficiencies of the fabricated magnetic nanosystem were calculated to be 96 ± 5 and 9.65 ± 0.5%, respectively. The drug release study results revealed that the developed drug delivery system (DDS) could be efficiently control the delivery of Dox in response to pH stimuli.

中文翻译：

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用于递送抗癌药物的新型 pH 响应磁性纳米系统

摘要

一种新型的 pH 响应磁性纳米系统被设计和开发用于癌症治疗。为此，通过使用可逆加成断裂链转移 (RAFT) 技术聚合甲基丙烯酸 2-羟乙酯 (HEMA) 单体和通过开环同时接枝 ε-己内酯 (ε-CL) 单体，合成了明确定义的三元共聚物聚合（ROP）方法，然后通过RAFT聚合方法将丙烯酸（AA）单体嵌段共聚，以生产聚（丙烯酸）-嵌段-[聚（甲基丙烯酸2-氧乙酯）-接枝-聚（ε-己内酯） )] [PAA- b -(POEMA- g -PCL)]。之后，磁铁矿纳米颗粒（Fe ₃ O ₄NPs) 通过化学共沉淀法合成，然后通过溶液混合方法通过物理相互作用（例如静电和氢键）结合到开发的三元共聚物中。盐酸多柔比星 (Dox) 作为抗癌模型药物，所制造的磁性纳米系统的负载 (LE) 和封装 (EE) 效率分别为 96 ± 5 和 9.65 ± 0.5%。药物释放研究结果表明，开发的药物递送系统（DDS）可以有效地控制 Dox 响应 pH 刺激的递送。