Poly (p-dioxanone) (PPDO) and poly (lactic acid) (PLA) were melt blended to prepare PPDO/PLA blends in this study, and 3D printing technology was used to prepare personalized pancreaticojejunostomy devices. By testing the degradation properties, mechanical properties, thermal stability, biocompatibility, hydrophilicity, and cell adhesion in vitro and in vivo, a suitable ratio of PPDO/PLA was selected as the material for the pancreaticojejunostomy device. The results show that the pancreaticojejunostomy device can be fabricated by PPDO/PLA blends using fused filament fabrication (FFF) 3D printing. As the proportion of PPDO increases, its degradation rate gradually increases, and its hydrophilicity improves, which is more conducive to cell adhesion and proliferation, while its mechanical properties gradually decrease. However, compared with soft tissues, it can still provide longer-term support strength to avoid early anastomotic stenosis. The mass loss rate in vivo was significantly faster than that in vitro, and the degradation rate of 50% PPDO/PLA at 3 months was 46.04 ± 5.79%. With the absorption and metabolism of the degradation products, there is no obvious toxic to the important organs in the body. Therefore, 50% PPDO/PLA has a suitable degradation time, mechanical properties, and good biocompatibility and has great application potential in manufacturing 3D pancreaticojejunostomy devices.

本研究将聚对二恶烷酮 (PPDO) 和聚乳酸 (PLA) 熔融共混制备 PPDO/PLA 共混物，并使用 3D 打印技术制备个性化胰空肠造口术装置。通过在体外和体内测试降解性能、机械性能、热稳定性、生物相容性、亲水性和细胞粘附性，选择合适比例的 PPDO/PLA 作为胰空肠吻合装置的材料。结果表明，可以使用 PPDO/PLA 混合物使用熔丝制造 (FFF) 3D 打印来制造胰空肠吻合装置。随着PPDO比例的增加，其降解速率逐渐增大，亲水性提高，更有利于细胞粘附和增殖，而其力学性能逐渐下降。然而，与软组织相比，仍能提供更长期的支撑强度，避免早期吻合口狭窄。体内质量损失率明显快于体外，3个月时50%PPDO/PLA的降解率为46.04±5.79%。随着降解产物的吸收和代谢，对体内重要器官无明显毒性。因此，50% PPDO/PLA 具有合适的降解时间、力学性能和良好的生物相容性，在制造 3D 胰空肠吻合装置方面具有巨大的应用潜力。随着降解产物的吸收和代谢，对体内重要器官无明显毒性。因此，50% PPDO/PLA 具有合适的降解时间、力学性能和良好的生物相容性，在制造 3D 胰空肠吻合装置方面具有巨大的应用潜力。随着降解产物的吸收和代谢，对体内重要器官无明显毒性。因此，50% PPDO/PLA 具有合适的降解时间、力学性能和良好的生物相容性，在制造 3D 胰空肠吻合装置方面具有巨大的应用潜力。