Poly(glycerol-sebacate-urethane) (PGS-U) is an attractive candidate as a super-elastic and biocompatible scaffold for inserting nanoparticles and polymers with a straightforward synthesis. Herein, a series of PGS-U scaffolds with various crosslink densities was prepared for subsequent polypyrrole (PPy) polymerization. The in-situ polymerization of PPy was employed to deposit the PPy particles throughout the scaffolds, and the continuous electrically conductive pathways were built within the scaffolds. Moreover, due to their favorable mechanical and anti-bacterial properties, zinc oxide (ZnO) nanoparticles were embedded within the scaffold. The composition of the scaffolds was confirmed by different characterization techniques, including FTIR, FE-SEM, and EDX. Static and cyclic compression tests were conducted to evaluate the mechanical performance of scaffolds under dry and hydrated conditions. All scaffolds presented high structural stability and full shape recovery after releasing the load. They were thermally stable up to at least 200 °C. The addition of PPy boosted the electrical conductivity, and the inclusion of ZnO particles improved the surface hydrophilicity and anti-bacterial behavior of the scaffolds. Altogether, this study suggests the further developments of these nanocomposites as satisfactory electrically conductive scaffolds for tissue engineering applications.

聚（甘油-癸二酸-氨基甲酸酯）（PGS-U）是一种极具吸引力的候选材料，可作为一种超弹性和生物相容性支架，用于通过直接合成插入纳米颗粒和聚合物。在此，制备了一系列具有不同交联密度的 PGS-U 支架用于后续的聚吡咯 (PPy) 聚合。在原位PPy 的聚合被用来将 PPy 颗粒沉积在整个支架上，并且在支架内建立了连续的导电通路。此外，由于其良好的机械和抗菌性能，氧化锌 (ZnO) 纳米颗粒嵌入支架内。支架的组成通过不同的表征技术得到证实，包括 FTIR、FE-SEM 和 EDX。进行静态和循环压缩测试以评估支架在干燥和水合条件下的机械性能。所有支架在释放负载后都表现出高度的结构稳定性和完全的形状恢复。它们在高达至少 200 °C 的温度下是热稳定的。PPy 的加入提高了电导率，ZnO 颗粒的加入提高了支架的表面亲水性和抗菌性能。总之，这项研究表明这些纳米复合材料作为组织工程应用的令人满意的导电支架的进一步发展。