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In Structural Glycobiology, Deuterium provides the Details
Structure ( IF 5.7 ) Pub Date : 2021-09-02 , DOI: 10.1016/j.str.2021.08.004
Gerardo R Vasta 1 , L Mario Amzel 2
Affiliation  

In this issue of Structure, Gadjos et al. (2021b) determine the structure of a bacterial lectin in complex with L-fucose by neutron diffraction of both perdeuterated protein and carbohydrate ligand. The structure provides insight into lectin-ligand interactions, opening avenues for drug design targeting bacterial lectins for intervention in infectious disease.



中文翻译:

在结构糖生物学中,氘提供了详细信息

在本期结构中,Gadjos 等人。(2021b) 通过过氘化蛋白质和碳水化合物配体的中子衍射,确定了与 L-岩藻糖复合的细菌凝集素的结构。该结构提供了对凝集素-配体相互作用的深入了解,为针对细菌凝集素的药物设计开辟了途径,以干预传染病。

更新日期:2021-09-02
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