Palladium catalyzes a domino Heck arylation and alkylation of nonconjugated cyclodienes to produce trans isomers of disubstituted cyclohexenes in exceptionally high enantiomeric ratios, reaching 100:1 to 200:1 in many cases. Importantly, the interactions of the two CF bonds of Josiphos and the sodium ion of malonates facilitates stereoselective allylic attack through DFT calculations and experiments. This is a new type of attractive noncovalent interactions found in organometallic catalysis.

中文翻译：

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非共轭二烯的不对称 Domino Heck 芳基化和烷基化：双 C–F……钠有吸引力的非共价相互作用

钯催化非共轭环二烯的多米诺 Heck 芳基化和烷基化，以极高的对映体比率产生双取代环己烯的反式异构体，在许多情况下达到 100:1 至 200:1。重要的是，Josiphos 的两个 CF 键和丙二酸酯的钠离子的相互作用通过 DFT 计算和实验促进了立体选择性烯丙基攻击。这是在有机金属催化中发现的一种新型有吸引力的非共价相互作用。