Chronic pain affects 7%–10% of Americans, occurs more frequently and severely in females, and available treatments have been shown to have less efficacy in female patients. Preclinical models addressing sex-specific treatment differences in the treatment of chronic pain have been limited. Here we examine the sex-specific effects of low intensity focused ultrasound (liFUS) in a modified sciatic nerve injury (SNI) model.

中文翻译：

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低强度聚焦超声可延长雌性腓总神经损伤大鼠的抗伤害反应持续时间

慢性疼痛影响着 7%–10% 的美国人，在女性中发生得更频繁、更严重，并且现有的治疗方法已被证明对女性患者疗效较差。解决慢性疼痛治疗中性别特异性治疗差异的临床前模型有限。在这里，我们研究了低强度聚焦超声 (liFUS) 在改良坐骨神经损伤 (SNI) 模型中的性别特异性效应。