Background and Purpose:Reversible cerebral vasoconstriction syndrome (RCVS) is a well-established cause of stroke, but its demographics and outcomes have not been well delineated.Methods:Analysis of the United States Nationwide Inpatient Sample database (2016–2017) to characterize the frequency of hospitalizations for RCVS, demographic features, inpatient mortality, and discharge outcomes.Results:During the 2-year study period, 2020 patients with RCVS were admitted to Nationwide Inpatient Sample hospitals, representing 0.02 cases per 100 000 national hospitalizations. The mean age at admission was 47.6 years, with 85% under 65 years of age, and 75.5% women. Concomitant neurological diagnoses during hospitalization included ischemic stroke (17.1%), intracerebral hemorrhage (11.0%), subarachnoid hemorrhage (32.7%), seizure disorders (6.7%), and reversible brain edema (13.6%). Overall, 70% of patients were discharged home, 29.7% discharged to a rehabilitation facility or nursing home and 0.3% died before discharge. Patient features independently associated with the poor outcome of discharge to another facility or death were advanced age (odds ratio [OR], 1.04 [95% CI, 1.03–1.04]), being a woman (OR, 2.45 [1.82–3.34]), intracerebral hemorrhage (OR, 2.91 [1.96–4.31]), ischemic stroke (OR, 5.72 [4.32–7.58]), seizure disorders (OR, 2.61 [1.70–4.00]), reversible brain edema (OR, 6.26 [4.41–8.89]), atrial fibrillation (OR, 2.97 [1.83–4.81]), and chronic kidney disease (OR, 3.43 [2.19–5.36]).Conclusions:Projected to the entire US population, >1000 patients with RCVS are hospitalized each year, with the majority being middle-aged women, and about 300 required at least some rehabilitation or nursing home care after discharge. RCVS-related inpatient mortality is rare.

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可逆性脑血管收缩综合征患者的结局：美国全国性分析

背景和目的：可逆性脑血管收缩综合征 (RCVS) 是公认的卒中原因，但其人口统计数据和结果尚未得到很好的描述。方法：分析美国全国住院患者样本数据库 (2016-2017) 以表征RCVS 住院频率、人口学特征、住院死亡率和出院结果。结果：在为期 2 年的研究期间，2020 名 RCVS 患者进入全国住院样本医院，每 100 000 例全国住院患者中有 0.02 例。入院时的平均年龄为 47.6 岁，其中 85% 年龄在 65 岁以下，75.5% 为女性。住院期间伴随的神经系统诊断包括缺血性中风（17.1%）、脑出血（11.0%）、蛛网膜下腔出血（32.7%）、癫痫发作（6.7%）、和可逆性脑水肿（13.6%）。总体而言，70% 的患者出院回家，29.7% 的患者出院到康复机构或疗养院，0.3% 的患者在出院前死亡。与出院或死亡的不良结局独立相关的患者特征是高龄（优势比 [OR]，1.04 [95% CI，1.03-1.04]），女性（OR，2.45 [1.82-3.34]） , 脑出血 (OR, 2.91 [1.96–4.31]), 缺血性中风 (OR, 5.72 [4.32–7.58]), 癫痫发作 (OR, 2.61 [1.70–4.00]), 可逆性脑水肿 (OR, 6.26 [4.41– 8.89])、心房颤动 (OR, 2.97 [1.83–4.81]) 和慢性肾病 (OR, 3.43 [2.19–5.36])。结论：预测到整个美国人口，每年有超过 1000 名 RCVS 患者住院，以中年女性居多，大约 300 人在出院后至少需要一些康复或疗养院护理。RCVS 相关的住院死亡率是罕见的。