Objective: The present study is to investigate the pre- and post-operative magnetic resonance imaging of pituitary tissues following transsphenoidal resection of pituitary macroadenomas, as well as its clinical significance.
Materials and Methods: The medical records of 108 consecutive pituitary macroadenoma patients admitted at Fuzhou 900^th Hospital between September 2012 and September 2014 were retrospectively reviewed. Siemens 3. 0T magnetic resonance scanner was used to perform pre- and postoperative MRI scanning, including plain scan and contrast-enhanced scan of SE sequential T1WI and T2WI in sagittal, coronal and axial views. PACS medical imaging system was used to measure the diameter of pituitary adenoma, as well as the volumes of the adenoma and pituitary tissue. Hematoxylin-eosin staining and immunohistochemical staining were also performed.
Results: Higher height of pituitary adenoma results in lower rate of posterior pituitary bright spot (PPBS) on MR T1-weighted imaging. Preoperative MR signal intensity of PPBS was negatively related to diabetes insipidus (DI). Normal pituitary tissues were likely to be above the pituitary adenomas in growth hormone-secreting adenoma patients, while mostly located aside in gonadotropin-secreting adenoma patients. Morphological restitution of postoperative pituitary tissues was better in lateral displacement than that in superior or superolateral patterns on pre-operative MR images. Positive rate of PPBS on preoperative MRI is negatively related to adenoma height, and the signal intensity of PPBS is inversely related to postoperative DI.
Conclusions: The relative locations of pituitary tissues and adenoma tissues may be associated with the adenoma type and may affect the postoperative remodeling of residual pituitary tissues.


中文翻译：

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垂体大腺瘤经蝶窦切除后残留垂体组织的磁共振成像特征


目的：本研究旨在探讨垂体大腺瘤经蝶窦切除术后垂体组织的磁共振成像及其临床意义。
材料与方法：福州900医院连续^收治的108例垂体大腺瘤患者的病历对 2012 年 9 月至 2014 年 9 月的医院进行回顾性分析。采用西门子3.0T磁共振扫描仪进行术前术后MRI扫描，包括矢状面、冠状面和轴位面SE序列T1WI和T2WI的平扫和对比增强扫描。PACS医学影像系统用于测量垂体腺瘤的直径，以及腺瘤和垂体组织的体积。还进行了苏木精-伊红染色和免疫组织化学染色。
结果：垂体腺瘤高度越高，MR T1 加权成像中垂体后叶亮点 (PPBS) 的发生率越低。PPBS术前MR信号强度与尿崩症（DI）呈负相关。在分泌生长激素的腺瘤患者中，正常垂体组织可能位于垂体腺瘤上方，而在分泌促性腺激素的腺瘤患者中，大部分位于垂体腺瘤的旁边。在术前 MR 图像上，侧向移位的垂体组织形态学恢复优于上外侧或上外侧模式。术前MRI PPBS阳性率与腺瘤高度呈负相关，PPBS信号强度与术后DI呈负相关。
结论：垂体组织与腺瘤组织的相对位置可能与腺瘤类型有关，并可能影响术后残余垂体组织的重塑。