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Transmembrane channel-like 4 is involved in pH and temperature-dependent modulation of salty taste.
Bioscience, Biotechnology, and Biochemistry ( IF 1.6 ) Pub Date : 2021-10-21 , DOI: 10.1093/bbb/zbab152
Yoichi Kasahara 1 , Masataka Narukawa 1, 2 , Shinji Kanda 3 , Makoto Tominaga 4, 5 , Keiko Abe 1, 6 , Takumi Misaka 1 , Tomiko Asakura 1
Affiliation  

Human susceptibility to NaCl varies depending on temperature and pH, the molecular mechanisms of which remain unclear. The voltage-dependent chloride channel, transmembrane channel-like 4 (TMC4), is activated at approximately 40 °C and is suppressed at pH 5.5. As these are similar in character to human sensory evaluations, human TMC4 may be involved in human salt taste reception.

中文翻译:

跨膜通道样 4 参与了对咸味的 pH 和温度依赖性调节。

人类对 NaCl 的敏感性因温度和 pH 值而异,其分子机制仍不清楚。电压依赖性氯离子通道,跨膜通道样 4 (TMC4),在大约 40 °C 时被激活,在 pH 5.5 时被抑制。由于这些在性质上与人类感官评估相似,因此人类 TMC4 可能参与人类盐味接收。
更新日期:2021-09-01
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