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Thalamic deep brain stimulation modulates circadian and infradian cycles of seizure risk in epilepsy
medRxiv - Neurology Pub Date : 2021-08-29 , DOI: 10.1101/2021.08.25.21262616
Nicholas M. Gregg , Vladimir Sladky , Petr Nejedly , Filip Mivalt , Inyong Kim , Irena Balzekas , Beverly K. Sturges , Chelsea Crowe , Edward E. Patterson , Jamie J. Van Gompel , Brian N. Lundstrom , Kent Leyde , Timothy J. Denison , Benjamin H. Brinkmann , Vaclav Kremen , Gregory A. Worrell

Chronic brain recordings suggest that seizure risk is not uniform, but rather varies systematically relative to daily (circadian) and multiday (infradian) cycles. Here, one human and seven dogs with naturally occurring epilepsy had continuous intracranial EEG (median 298 days) using novel implantable sensing and stimulation devices. Two pet dogs and the human subject received concurrent thalamic deep brain stimulation (DBS) over multiple months. All subjects had circadian and infradian cycles in the rate of interictal epileptiform spikes (IES). There was seizure phase locking to circadian and infradian IES cycles in five and seven out of eight subjects, respectively. Thalamic DBS modified circadian (all 3 subjects) and infradian (analysis limited to the human participant) IES cycles. DBS modified seizure clustering and circadian phase locking in the human subject. Multiscale cycles in brain excitability and seizure risk are features of human and canine epilepsy and are modifiable by thalamic DBS.

中文翻译:

丘脑深部脑刺激调节癫痫发作风险的昼夜节律和节律周期

慢性脑部记录表明癫痫发作风险并不统一,而是相对于每日(昼夜节律)和多日(infradian)周期系统地变化。在这里,一名患有自然癫痫的人和七只狗使用新型植入式传感和刺激设备进行了连续颅内 EEG(中位数 298 天)。两只宠物狗和人类受试者在数月内同时接受了丘脑深部脑刺激 (DBS)。所有受试者的发作间期癫痫样尖峰 (IES) 率都有昼夜节律和亚节律周期。八名受试者中的五名和七名分别对昼夜节律和红外线 IES 周期进行了癫痫相位锁定。丘脑 DBS 修改了昼夜节律(所有 3 名受试者)和 infradian(分析仅限于人类参与者)IES 周期。DBS 修改了人类受试者的癫痫发作聚类和昼夜节律相位锁定。大脑兴奋性和癫痫发作风险的多尺度循环是人类和犬癫痫的特征,并且可以通过丘脑 DBS 进行修改。
更新日期:2021-09-01
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