Aptamers play an important role in biomedical industry due to their great affinity to bind to target site. Due to their targeting potency, an adequate amount of therapeutically active drug could be internalized inside the tumor cells. However, development of functionalized aptamer is hindered due to degradation by endonuclease. A bioconjugation of aptamer based dendrimer delivery could grant a new platform of improved targeted drug delivery system. Dendrimers are synthetic molecule with high ligand binding capability due to presence of enormous functional group on their periphery. Unlike other class of polymer, they serve as a biocompatible and stable vehicle with high drug loading efficiency. In this review, we have discussed about the role of aptamer in pharmaceutical industry along with potential of dendrimer as a novel carrier having high ligand binding capability. The review majorly focused on delivery of anticancer drugs and genetic agents to various neoplastic cells.

适体由于其与靶位点的结合具有很强的亲和力，因此在生物医学工业中发挥着重要作用。由于它们的靶向效力，足量的治疗活性药物可以被内化到肿瘤细胞内。然而，由于核酸内切酶的降解，功能化适体的开发受到阻碍。基于适配体的树枝状聚合物递送的生物偶联可以为改进的靶向药物递送系统提供一个新平台。树枝状聚合物是一种合成分子，由于其外围存在大量的官能团，因此具有高配体结合能力。与其他类别的聚合物不同，它们作为一种生物相容性和稳定的载体，具有高载药效率。在这次审查中，我们已经讨论了适体在制药工业中的作用以及树枝状聚合物作为具有高配体结合能力的新型载体的潜力。该综述主要集中在向各种肿瘤细胞输送抗癌药物和遗传物质。