A facile and efficient acid-catalyzed three-component reaction of indoles, 1-tosyl-1,2,3-triazoles and carbonyl compounds has been developed. The use of TsOH with a small amount of water significantly promoted the reaction yield. This method provided a general and one-pot approach for the synthesis of structurally diverse C3-alkylated indole derivatives. The alkylation exclusively occurred at the N² position of triazoles. Various functional groups were tolerated under the optimized simple reaction conditions.

中文翻译：

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羰基化合物与1,2,3-三唑和吲哚的酸催化三组分加成

开发了一种简便高效的酸催化吲哚、1-甲苯磺酰基-1,2,3-三唑和羰基化合物的三组分反应。TsOH与少量水的使用显着提高了反应产率。该方法为合成结构多样的C 3-烷基化吲哚衍生物提供了一种通用的一锅法。烷基化仅发生在三唑的N ²位。在优化的简单反应条件下可以耐受各种官能团。