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Copper-doped mesoporous bioactive glass endows magnesium-based scaffold with antibacterial activity and corrosion resistance
Materials Chemistry Frontiers ( IF 7 ) Pub Date : 2021-08-17 , DOI: 10.1039/d1qm01028j
Youwen Yang 1 , Changfu Lu 1 , Mingli Yang 1 , Dongsheng Wang 2 , Shuping Peng 3 , Zongjun Tian 1, 4 , Cijun Shuai 1, 5, 6
Affiliation  

A biodegradable magnesium (Mg) scaffold as bone repair material is desired to demonstrate antibacterial function to reduce the risk of bacterial infection. In this work, mesoporous bioactive glass (MBG) was used as a carrier of copper (Cu) ions to obtain Cu-doped MBG (Cu-MBG), which was then incorporated into a Mg-based scaffold fabricated by laser additive manufacturing. Results showed that Cu-MBG endowed the Mg-based scaffold with favorable antibacterial activity, with an antibacterial rate of 81% (against E. coli), owing to the sustained release of Cu2+ ions from Cu-MBG. More significantly, Cu-MBG with excellent bioactivity effectively induced the in situ deposition of the apatite product, which served as a protective layer and consequently reduced the degradation rate of the Mg matrix. Furthermore, Cu-MBG improved the cell response, including cell growth and adhesion. This study proposed a new strategy to simultaneously improve the antibacterial activity, degradation behavior and cell response of the biomedical Mg-based material.

中文翻译:

铜掺杂介孔生物活性玻璃赋予镁基支架抗菌活性和耐腐蚀性

需要可生物降解的镁 (Mg) 支架作为骨修复材料来展示抗菌功能以降低细菌感染的风险。在这项工作中,介孔生物活性玻璃 (MBG) 被用作铜 (Cu) 离子的载体,以获得铜掺杂的 MBG (Cu-MBG),然后将其结合到通过激光增材制造制造的镁基支架中。结果表明,由于 Cu-MBG持续释放 Cu 2+离子,Cu-MBG 赋予镁基支架良好的抗菌活性,抗菌率为 81%(对大肠杆菌)。更重要的是,具有优异生物活性的 Cu-MBG 有效地诱导了原位磷灰石产物的沉积,作为保护层,因此降低了镁基体的降解速率。此外,Cu-MBG 改善了细胞反应,包括细胞生长和粘附。该研究提出了一种新策略,可以同时提高生物医用镁基材料的抗菌活性、降解行为和细胞反应。
更新日期:2021-09-01
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