Objective:

Prior research suggests that restless leg syndrome (RLS) is prevalent in Parkinson’s disease (PD) with insufficient evidence to support the relationship between RLS, PD, and pain. This study explored the relationship between pain in PD patients and its association with the prevalence and severity of RLS.

Method:

127 PD patients were assessed for PD and RLS using the U.K. Brain bank Criteria and the Restless Leg Syndrome diagnostic criteria, respectively. These patients were also assessed for pain perception and interference using the Brief Pain Inventory.

Results:

The results demonstrated Parkinson’s disease patients who reported pain scored 23 more Restless Leg Syndrome prevalence points (p < 0.05), and 8.5 counts higher for Restless Leg Syndrome severity (p < 0.05) compared to the group of Parkinson’s disease patients denying pain.

Discussion:

The presence of pain in PD patients indicated a higher RLS prevalence and an increased RLS severity. This finding suggests patients suffering from pain interference may experience more severe RLS symptoms. This demonstrates an inextricable link and association between pain in PD patients and RLS. Further robust investigations are required to elucidate any potential causative links, which can inform more holistic treatment principles.

中文翻译：

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横截面设计：帕金森疼痛与不宁腿综合征之间的联系

客观的：

先前的研究表明，不宁腿综合征 (RLS) 在帕金森病 (PD) 中普遍存在，但没有足够的证据支持 RLS、PD 和疼痛之间的关系。本研究探讨了 PD 患者疼痛及其与 RLS 患病率和严重程度之间的关系。

方法：

分别使用英国脑库标准和不安腿综合征诊断标准评估了 127 名 PD 患者的 PD 和 RLS。还使用简要疼痛量表评估这些患者的疼痛感知和干扰。

结果：

结果表明，与否认疼痛的帕金森病患者组相比，报告疼痛的帕金森病患者的不安腿综合征患病率高出 23 个（ p < 0.05），不安腿综合症严重程度高 8.5分（ p < 0.05）。

讨论：

PD 患者存在疼痛表明 RLS 患病率较高，RLS 严重程度增加。这一发现表明，患有疼痛干扰的患者可能会出现更严重的 RLS 症状。这表明 PD 患者的疼痛与 RLS 之间存在不可分割的联系和关联。需要进一步强有力的调查来阐明任何潜在的因果关系，这可以为更全面的治疗原则提供信息。