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G-Quadruplex Assembly by Ribosomal DNA: Emerging Roles in Disease Pathogenesis and Cancer Biology
Cytogenetic and Genome Research ( IF 1.7 ) Pub Date : 2021-09-01 , DOI: 10.1159/000516394
Arindam Datta 1 , Kevin J Pollock 2 , Karen A Kormuth 2 , Robert M Brosh 1
Affiliation  

Unique repetitive elements of the eukaryotic genome can be problematic for cellular DNA replication and transcription and pose a source of genomic instability. Human ribosomal DNA (rDNA) exists as repeating units clustered together on several chromosomes. Understanding the molecular mechanisms whereby rDNA interferes with normal genome homeostasis is the subject of this review. We discuss the instability of rDNA as a driver of senescence and the important roles of helicases to suppress its deleterious effects. The propensity of rDNA that is rich in guanine bases to form G-quadruplexes (G4) is discussed and evaluated in disease pathogenesis. Targeting G4 in the ribosomes and other chromosomal loci may represent a useful synthetic lethal approach to combating cancer.
Cytogenet Genome Res


中文翻译:

核糖体 DNA 组装 G-四链体:在疾病发病机制和癌症生物学中的新作用

真核基因组的独特重复元件可能对细胞 DNA 复制和转录造成问题,并构成基因组不稳定性的根源。人类核糖体 DNA (rDNA) 以重复单元的形式存在,这些重复单元聚集在几条染色体上。了解 rDNA 干扰正常基因组稳态的分子机制是本综述的主题。我们讨论了 rDNA 作为衰老驱动因素的不稳定性以及解旋酶抑制其有害影响的重要作用。在疾病发病机制中讨论和评估了富含鸟嘌呤碱基的 rDNA 形成 G-四链体 (G4) 的倾向。靶向核糖体和其他染色体基因座中的 G4 可能代表一种有用的合成致死方法来对抗癌症。
细胞基因组研究
更新日期:2021-09-01
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