Systemic sclerosis (SSc) is a multiorgan autoimmune disease characterized by inflammation, vascular modification, and progressive fibrosis of the skin and several visceral organs. Innate and adaptive immune cells, including myeloid, B and T cells, are believed to be central to the pathogenesis of SSc. However, the role and functional state of neutrophil granulocytes (neutrophils) are ill-defined in SSc.

中文翻译：

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系统性硬化症患者中性粒细胞表现出表型和功能缺陷

系统性硬化症 (SSc) 是一种多器官自身免疫性疾病，其特征是皮肤和几个内脏器官的炎症、血管改变和进行性纤维化。先天性和适应性免疫细胞，包括骨髓、B 和 T 细胞，被认为是 SSc 发病机制的核心。然而，中性粒细胞（中性粒细胞）的作用和功能状态在 SSc 中的定义不明确。