Genetic Characterization of a Novel HIV-1 Second-Generation Recombinant Form Originating from CRF86_BC and a Unique Recombinant Form in Yunnan, China,AIDS Research and Human Retroviruses

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Genetic Characterization of a Novel HIV-1 Second-Generation Recombinant Form Originating from CRF86_BC and a Unique Recombinant Form in Yunnan, China
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2021-12-15 , DOI: 10.1089/aid.2021.0121
Ya-Ting Chen _{1,

2} , Zheng-Xu Li ₃ , Ying-Na Xie ₁ , Lei Zhao ₁ , An-Yan Hu ₃ , Li An ₃ , Xian-Ya Dong ₃ , Dong-Xu Liu ₁ , Qiang Ma ₃ , Xin Chen ₁

Affiliation

Yunnan is the first place where human immunodeficiency virus type 1 (HIV-1) became prevalent in China, and it is also the place with the most complicated HIV-1 genetic diversity in China. On October 23, 2019, a patient newly diagnosed with acquired immunodeficiency syndrome from a hospital in Baoshan, Yunnan, was recruited for genetic analysis. Near full-length genome of HIV-1 was amplified from the plasma sample. Phylogenetic analysis revealed that this sequence (BS6F24) has a close relationship with CRF86_BC and a unique recombinant form (URF) (KY406739), which was formed by recombination of subtypes B and C. Bootscan analysis confirmed that the first part (HXB2:1022-5832) and last part (HXB2:5833-9120) genomes of BS6F24 had the same recombinant structures as KY406739 and CRF86_BC, respectively. A second-generation recombinant form that originated from CRF86_BC and a URF were reported for the first time. This indicates the need for continuous monitoring of the genetic diversity of HIV-1 in Yunnan, China.

更新日期：2021-12-28

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