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Synergistic antibacterial effect of graphene-coated titanium loaded with levofloxacin
Colloids and Surfaces B: Biointerfaces ( IF 5.8 ) Pub Date : 2021-09-01 , DOI: 10.1016/j.colsurfb.2021.112090
Jiayue Sun 1 , Xuling Liu 1 , Chengqi Lyu 1 , Yinghan Hu 1 , Derong Zou 1 , Yu-Shi He 2 , Jiayu Lu 1
Affiliation  

In this study, graphene coating was introduced to the modified titanium surface to prevent bacterial infection in oral implants. We modified the titanium surface through SLA and silanization treatment and then coated the surface with graphene. The structure and surface properties were characterized by XPS and SEM. Graphene-coated titanium sheet was incubated with bacteria to test the antibacterial property, which was enhanced by adsorption and release of levofloxacin. We further implanted the graphene-coated titanium sheet loaded with levofloxacin into rabbits to test the antibacterial properties in vivo. The graphene coating exhibited inherent antibacterial properties through membrane stress and the generation of reactive oxygen species (ROS). When loaded with levofloxacin, the graphene coating exhibited a synergistic antibacterial effect and effectively prevented bacterial infections following the implantation. The graphene coating is promising to improve the antibacterial functions of oral implant surfaces to prevent bacterial infection.



中文翻译:

载有左氧氟沙星的石墨烯包覆钛的协同抗菌作用

在这项研究中,石墨烯涂层被引入到改性钛表面以防止口腔植入物中的细菌感染。我们通过 SLA 和硅烷化处理对钛表面进行改性,然后在表面涂上石墨烯。通过XPS和SEM表征结构和表面性质。石墨烯涂层钛板与细菌一起孵育以测试抗菌性能​​,该性能通过左氧氟沙星的吸附和释放增强。我们进一步将载有左氧氟沙星的石墨烯涂层钛片植入兔体内,以测试其体内抗菌性能. 石墨烯涂层通过膜应力和活性氧 (ROS) 的产生表现出固有的抗菌性能。当加载左氧氟沙星时,石墨烯涂层表现出协同抗菌作用,有效防止植入后的细菌感染。石墨烯涂层有望提高口腔种植体表面的抗菌功能,防止细菌感染。

更新日期:2021-09-08
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